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Literature summary extracted from

  • Murthy, K.S.; Zhou, H.
    Selective phosphorylation of the IP3R-I in vivo by cGMP-dependent protein kinase in smooth muscle (2003), Am. J. Physiol. Gastronintest. Liver Physiol., 284, G221-230.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP
-
 Oryctolagus cuniculus
2.7.11.11 cBIMPS
-
 Oryctolagus cuniculus
2.7.11.11 forskolin activates at concentration above 0.001 mM Oryctolagus cuniculus
2.7.11.11 isoproterenol at concentration below 0.001 mM Oryctolagus cuniculus
2.7.11.11 Vasoactive intestinal peptide i.e. VIP Oryctolagus cuniculus
2.7.11.12 8-pCPT-CGMP i.e. 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate, 358% activation, inhibitor KT5823 abolishes the activating effect Oryctolagus cuniculus
2.7.11.12 cAMP crossactivation at high levels in vivo Oryctolagus cuniculus
2.7.11.12 cGMP
-
 Oryctolagus cuniculus
2.7.11.12 forskolin crossactivation at high levels above 0.001 mM in vivo Oryctolagus cuniculus
2.7.11.12 isoproterenol crossactivation at high levels above 0.001 mM in vivo Oryctolagus cuniculus
2.7.11.12 sodium nitroprusside i.e. SNP, selective activator of PKG, 414% activation, inhibitor KT5823 abolishes the activating effect Oryctolagus cuniculus
2.7.11.12 Vasoactive intestinal peptide i.e. VIP Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.11 myristoylated PKI14-22 amide selective peptide inhibitor of P KA Oryctolagus cuniculus
2.7.11.12 KT5823 i.e. (8R,9S,11S)-(-)-9-methoxy-carbamyl-8-methyl-2,3,9,10-tetrahydro-8,11-epoxy-1H,8H-2,7b,11a-trizadizobenzo9(a,g)cycloocta(c,d,e)-trinden-1-one, selective PKG inhibitor Oryctolagus cuniculus
2.7.11.12 additional information no inhibition by myristoylated PKI14-22 amide Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Oryctolagus cuniculus
2.7.11.12 Mg2+
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 additional information Oryctolagus cuniculus inositol 1,4,5-trisphosphate receptor-I is no substrate of PKA in vivo ?
-
 ?
2.7.11.12 ATP + inositol 1,4,5-trisphosphate receptor-I Oryctolagus cuniculus the phosphorylation of the receptor inhibits inositol 1,4,5-trisphosphate-induced Ca2+ release ADP + phosphorylated inositol 1,4,5-trisphosphate receptor-I
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Oryctolagus cuniculus
-
-
-
2.7.11.12 Oryctolagus cuniculus
-
 isozymes PKG-Ialpha and PKG-Ibeta
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.12 isozyme PKG-Ialpha Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 smooth muscle cell gastric, primary Oryctolagus cuniculus
-
2.7.11.11 stomach
-
 Oryctolagus cuniculus
-
2.7.11.12 smooth muscle gastric, primary Oryctolagus cuniculus
-
2.7.11.12 stomach
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + inositol 1,4,5-trisphosphate receptor-I isolated catalytic subunit of PKA, selective phosphorylation at Ser1589 and Ser1755 Oryctolagus cuniculus ADP + phosphorylated inositol 1,4,5-trisphosphate receptor-I
-
 ?
2.7.11.11 additional information inositol 1,4,5-trisphosphate receptor-I is no substrate of PKA in vivo Oryctolagus cuniculus ?
-
 ?
2.7.11.12 ATP + inositol 1,4,5-trisphosphate receptor-I the phosphorylation of the receptor inhibits inositol 1,4,5-trisphosphate-induced Ca2+ release Oryctolagus cuniculus ADP + phosphorylated inositol 1,4,5-trisphosphate receptor-I
-
 ?
2.7.11.12 ATP + inositol 1,4,5-trisphosphate receptor-I selective phosphorylation at Ser1755 Oryctolagus cuniculus ADP + phosphorylated inositol 1,4,5-trisphosphate receptor-I
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Oryctolagus cuniculus
2.7.11.12 PKG
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.11 31
-
 in vivo phosphorylation assay at Oryctolagus cuniculus
2.7.11.12 31
-
 in vivo phosphorylation assay at Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.11 7.4
-
 assay at Oryctolagus cuniculus
2.7.11.12 7.4
-
 assay at Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Oryctolagus cuniculus
2.7.11.12 ATP
-
 Oryctolagus cuniculus