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Literature summary extracted from

  • Ricks, C.A.; Cook, R.M.
    Regulation of volatile fatty acid uptake by mitochondrial acyl CoA synthetases of bovine liver (1981), J. Dairy Sci., 64, 2324-2335.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.17 0.63
-
CoA
-
Bos taurus
6.2.1.17 1.3
-
propanoate ATP, propanoate Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.17 mitochondrion
-
Bos taurus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.2.1.17 35000
-
2 * 35000, SDS-PAGE Bos taurus
6.2.1.17 73400
-
sucrose density gradient centrifugation Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.17 ATP + propanoate + CoA Bos taurus the distinct propionyl CoA synthetase regulated by the concentration of propanoate in portal blood is significant because a primary role of ruminant liver is to synthesize glucose from ruminally derived propanoate ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.17 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.17 liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.2.1.17 3.36
-
-
Bos taurus

Storage Stability

EC Number Storage Stability Organism
6.2.1.17 -20°C, 10% glycerol, stable for months Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.17 ATP + acetate + CoA no activity Bos taurus AMP + diphosphate + acetyl-CoA
-
?
6.2.1.17 ATP + acrylate + CoA 85% of the activity relative to propanoate Bos taurus AMP + diphosphate + acryloyl-CoA
-
?
6.2.1.17 ATP + butyrate + CoA no activity Bos taurus AMP + diphosphate + butyryl-CoA
-
?
6.2.1.17 ATP + crotonate + CoA 13% of the activity relative to propanoate Bos taurus AMP + diphosphate + crotonyl-CoA
-
?
6.2.1.17 ATP + propanoate + CoA
-
Bos taurus AMP + diphosphate + propanoyl-CoA
-
?
6.2.1.17 ATP + propanoate + CoA the distinct propionyl CoA synthetase regulated by the concentration of propanoate in portal blood is significant because a primary role of ruminant liver is to synthesize glucose from ruminally derived propanoate Bos taurus ?
-
?
6.2.1.17 ATP + salicylate + CoA 8% of the activity relative to propanoate Bos taurus AMP + diphosphate + salicyl-CoA
-
?

Subunits

EC Number Subunits Comment Organism
6.2.1.17 dimer 2 * 35000, SDS-PAGE Bos taurus