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Literature summary extracted from
- Free fatty acids inhibit the activity of Clostridium histolyticum collagenase and human neutrophil elastase (2002), Planta Med., 68, 767-769.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.3 | erucic acid | IC50: 0.415 mM | Hathewaya histolytica |  |
| 3.4.24.3 | heptadecanoic acid | IC50: 0.03 mM | Hathewaya histolytica | |
| 3.4.24.3 | linoleic acid | IC50: 0.375 mM | Hathewaya histolytica | |
| 3.4.24.3 | linolenic acid | IC50: 0.46 mM | Hathewaya histolytica | |
| 3.4.24.3 | additional information | no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid | Hathewaya histolytica | |
| 3.4.24.3 | myristic acid | IC50: 0.27 mM | Hathewaya histolytica | |
| 3.4.24.3 | nonadecanoic acid | 0.045 mM | Hathewaya histolytica | |
| 3.4.24.3 | oleic acid | IC50: 0.46 mM | Hathewaya histolytica | |
| 3.4.24.3 | palmitic acid | IC50: 0.035 mM | Hathewaya histolytica | |
| 3.4.24.3 | palmitoleic acid | IC50: 0.405 mM | Hathewaya histolytica | |
| 3.4.24.3 | pentadecanoic acid | IC50: 0.125 mM | Hathewaya histolytica | |
| 3.4.24.3 | stearic acid | IC50: 0.03 mM | Hathewaya histolytica | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.3 | Hathewaya histolytica | - |
- |
- |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.24.3 | 0.03 | - |
IC50: 0.03 mM | Hathewaya histolytica | stearic acid | |
| 3.4.24.3 | 0.03 | - |
IC50: 0.03 mM | Hathewaya histolytica | heptadecanoic acid | |
| 3.4.24.3 | 0.035 | - |
IC50: 0.035 mM | Hathewaya histolytica | cabozantinib | |
| 3.4.24.3 | 0.125 | - |
IC50: 0.125 mM | Hathewaya histolytica | pentadecanoic acid | |
| 3.4.24.3 | 0.27 | - |
IC50: 0.27 mM | Hathewaya histolytica | myristic acid | |
| 3.4.24.3 | 0.375 | - |
IC50: 0.375 mM | Hathewaya histolytica | linoleic acid | |
| 3.4.24.3 | 0.405 | - |
IC50: 0.405 mM | Hathewaya histolytica | palmitoleic acid | |
| 3.4.24.3 | 0.415 | - |
IC50: 0.415 mM | Hathewaya histolytica | erucic acid | |
| 3.4.24.3 | 0.46 | - |
IC50: 0.46 mM | Hathewaya histolytica | oleic acid | |
| 3.4.24.3 | 0.46 | - |
IC50: 0.46 mM | Hathewaya histolytica | linolenic acid | |
| 3.4.24.3 | 0.5 | - |
no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid | Hathewaya histolytica | additional information |
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