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Literature summary extracted from

  • Munagala, N.R.; Wang, C.C.
    Adenosine is the primary precursor of all purine nucleotides in Trichomonas vaginalis (2003), Mol. Biochem. Parasitol., 127, 143-149.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.143 Formycin A IC50 is 0.00027 mM, inhibits growth of Trichomonas vaginalis, addition of adenine prevents growth inhibition, but not the addition of guanine and hypoxanthine Trichomonas vaginalis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.143 cytoplasm
-
 Trichomonas vaginalis 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.143 diphosphate + adenosine Trichomonas vaginalis
-
 phosphate + AMP
-
 ?
2.7.1.143 diphosphate + adenosine Trichomonas vaginalis 3001
-
 phosphate + AMP
-
 ?
2.7.1.143 diphosphate + guanosine Trichomonas vaginalis
-
 phosphate + GMP
-
 ?
2.7.1.143 diphosphate + guanosine Trichomonas vaginalis 3001
-
 phosphate + GMP
-
 ?
2.7.1.143 diphosphate + inosine Trichomonas vaginalis
-
 phosphate + IMP
-
 ?
2.7.1.143 additional information Trichomonas vaginalis adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview ?
-
 ?
2.7.1.143 additional information Trichomonas vaginalis 3001 adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview ?
-
 ?
6.3.5.2 additional information Trichomonas vaginalis enzyme of the purine salvage pathway ?
-
 ?
6.3.5.2 additional information Trichomonas vaginalis 3001 enzyme of the purine salvage pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.143 Trichomonas vaginalis
-
-
-
2.7.1.143 Trichomonas vaginalis 3001
-
-
-
6.3.5.2 Trichomonas vaginalis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.143 partially by ATP affinity chromatography Trichomonas vaginalis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.143 additional information the organism can grow on adenine, but not on guanine or hypoxanthine added to the culture medium Trichomonas vaginalis
-
2.7.1.143 trophozoite
-
 Trichomonas vaginalis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.143 diphosphate + adenosine
-
 Trichomonas vaginalis phosphate + AMP
-
 ?
2.7.1.143 diphosphate + adenosine
-
 Trichomonas vaginalis 3001 phosphate + AMP
-
 ?
2.7.1.143 diphosphate + guanosine
-
 Trichomonas vaginalis phosphate + GMP
-
 ?
2.7.1.143 diphosphate + guanosine
-
 Trichomonas vaginalis 3001 phosphate + GMP
-
 ?
2.7.1.143 diphosphate + inosine
-
 Trichomonas vaginalis phosphate + IMP
-
 ?
2.7.1.143 additional information adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview Trichomonas vaginalis ?
-
 ?
2.7.1.143 additional information adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview Trichomonas vaginalis 3001 ?
-
 ?
6.3.5.2 ATP + xanthosine 5'-phosphate + Gln
-
 Trichomonas vaginalis AMP + diphosphate + Glu
-
 ?
6.3.5.2 ATP + xanthosine 5'-phosphate + Gln
-
 Trichomonas vaginalis 3001 AMP + diphosphate + Glu
-
 ?
6.3.5.2 additional information enzyme of the purine salvage pathway Trichomonas vaginalis ?
-
 ?
6.3.5.2 additional information enzyme of the purine salvage pathway Trichomonas vaginalis 3001 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.143 PNK
-
 Trichomonas vaginalis
2.7.1.143 purine nucleoside kinase
-
 Trichomonas vaginalis
6.3.5.2 GMP synthetase
-
 Trichomonas vaginalis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.143 37
-
 assay at Trichomonas vaginalis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.143 7.2
-
 assay at Trichomonas vaginalis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.143 0.00027
-
 IC50 is 0.00027 mM, inhibits growth of Trichomonas vaginalis, addition of adenine prevents growth inhibition, but not the addition of guanine and hypoxanthine Trichomonas vaginalis Formycin A