EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | 1-oleoyl-rac-glycerol | approx. 20% stimulation at 0.4-0.8 mM, inhibition above | Rattus norvegicus | |
3.1.4.12 | 1-stearoyl-rac-glycerol | approx. 10% stimulation at 0.8 mM, inhibition above | Rattus norvegicus | |
3.1.4.12 | arachidonic acid | approx. 20% stimulation at 0.4-0.8 mM, inhibition above | Rattus norvegicus | |
3.1.4.12 | linoleic acid | approx. 20% stimulation at 0.8 mM, inhibition above | Rattus norvegicus | |
3.1.4.12 | linolenic acid | approx. 30% stimulation at 0.8-1.6 mM, inhibition above | Rattus norvegicus | |
3.1.4.12 | oleic acid | approx. 40% stimulation at 0.8 mM, inhibition above | Rattus norvegicus | |
3.1.4.12 | stearic acid | approx. 20% stimulation at 0.4-0.8 mM, inhibition above | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | 1,2-dioleoyl-sn-glycerol | approx. 40% inhibition at 3.2 mM | Rattus norvegicus | |
3.1.4.12 | 1,2-distearoyl-rac-glycerol | approx. 30% inhibition at 3.2 mM | Rattus norvegicus | |
3.1.4.12 | 1-oleoyl-rac-glycerol | slight stimulation below 0.8 mM, approx. 50% inhibition at 3.2 mM | Rattus norvegicus | |
3.1.4.12 | 1-stearoyl-rac-glycerol | slight stimulation below 0.8 mM, approx. 10% inhibition at 3.2 mM | Rattus norvegicus | |
3.1.4.12 | arachidonic acid | slight stimulation below 0.8 mM, approx. 50% inhibition at 3.2 mM | Rattus norvegicus | |
3.1.4.12 | ceramide | strong inhibition in the presence of 0.4 mM linoleic acid | Rattus norvegicus | |
3.1.4.12 | cholesterol | strong inhibition in the presence of 0.4 mM linoleic acid | Rattus norvegicus | |
3.1.4.12 | linoleic acid | slight stimulation below 0.8 mM, approx. 45% inhibition at 3.2 mM | Rattus norvegicus | |
3.1.4.12 | linolenic acid | stimulation below 0.8 mM, approx. 15% inhibition at 3.2 mM | Rattus norvegicus | |
3.1.4.12 | oleic acid | stimulation below 0.8 mM, approx. 10% inhibition at 3.2 mM | Rattus norvegicus | |
3.1.4.12 | stearic acid | slight stimulation below 0.8 mM, approx. 10% inhibition at 3.2 mM | Rattus norvegicus | |
3.1.4.12 | triolein | approx. 30% inhibition at 3.2 mM | Rattus norvegicus | |
3.1.4.12 | tristearin | approx. 35% inhibition at 3.2 mM | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | sphingomyelin + H2O | Rattus norvegicus | - |
N-acylsphingosine + choline phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.12 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.1.4.12 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.12 | intestine | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | sphingomyelin + H2O | - |
Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.12 | alkaline SMase | - |
Rattus norvegicus |
3.1.4.12 | alkaline sphingomyelinase | - |
Rattus norvegicus |