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Literature summary extracted from

  • Abramic, M.; Schleuder, D.; Dolovcak, L.; Schroder, W.; Strupat, K.; Sagi, D.; Peter-Katalini, J.; Vitale, L.
    Human and rat dipeptidyl peptidase III: biochemical and mass spectrometric arguments for similarities and differences (2000), Biol. Chem., 381, 1233-1243.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.4 amastatin 30% inhibition at 0.1 mM Rattus norvegicus
3.4.14.4 angiotensin II
-
 Homo sapiens
3.4.14.4 angiotensin II
-
 Rattus norvegicus
3.4.14.4 angiotensin III
-
 Homo sapiens
3.4.14.4 angiotensin III
-
 Rattus norvegicus
3.4.14.4 bestatin 10% inhibition at 0.1 mM Homo sapiens
3.4.14.4 bestatin 35% inhibition at 0.1 mM Rattus norvegicus
3.4.14.4 Co2+ activation up to 50% at 0.001-0.0001 mM, inbhibitory above 0.002 mM Rattus norvegicus
3.4.14.4 E-64 i.e. L-trans-epoxysuccinyl-leucylamido(4-guanidino)butane, 10% inhibition at 0.1 mM Rattus norvegicus
3.4.14.4 EDTA 67% inhibition at 5 mM Homo sapiens
3.4.14.4 Gly-Gly-Phe-Leu fragment of Leu-enkephalin Homo sapiens
3.4.14.4 Gly-Gly-Phe-Leu fragment of Leu-enkephalin Rattus norvegicus
3.4.14.4 His-Phe-Arg-Trp fragment of alpha-melanocyte-stimulating hormone Homo sapiens
3.4.14.4 His-Phe-Arg-Trp fragment of alpha-melanocyte-stimulating hormone Rattus norvegicus
3.4.14.4 Leu-Trp-Met-Arg-Phe
-
 Homo sapiens
3.4.14.4 Leu-Trp-Met-Arg-Phe
-
 Rattus norvegicus
3.4.14.4 leupeptin 10% inhibition at 0.1 mM Homo sapiens
3.4.14.4 Lys-Val-Ile-Leu-Phe fragment of hydra head activator Homo sapiens
3.4.14.4 Lys-Val-Ile-Leu-Phe fragment of hydra ‘head activator’ Rattus norvegicus
3.4.14.4 Nalpha-tosyl-L-Phe-chloromethyl ketone 60% inhibition at 0.1 mM Rattus norvegicus
3.4.14.4 o-phenanthroline 93% inhibition at 1 mM Homo sapiens
3.4.14.4 o-phenanthroline 50% inhibition at 0.1 mM Rattus norvegicus
3.4.14.4 PMSF 40% inhibition at 1 mM Rattus norvegicus
3.4.14.4 probestin 85% inhibition at 0.1 mM Rattus norvegicus
3.4.14.4 Proctolin
-
 Homo sapiens
3.4.14.4 Proctolin
-
 Rattus norvegicus
3.4.14.4 puromycin 15% inhibition at 0.1 mM Rattus norvegicus
3.4.14.4 Tyr-Gly-Gly-Phe-Leu Leu-enkephalin Homo sapiens
3.4.14.4 Tyr-Gly-Gly-Phe-Leu Leu-enkephalin Rattus norvegicus
3.4.14.4 Tyr-Gly-Gly-Phe-Met Met-enkephalin Homo sapiens
3.4.14.4 Tyr-Gly-Gly-Phe-Met Met-enkephalin Rattus norvegicus
3.4.14.4 Zn2+ 50% inhibition at 0.032 mM Homo sapiens
3.4.14.4 Zn2+ 50% inhibition at 0.001 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.14.4 0.00621
-
 Arg-Arg-2-naphthylamide pH 7.4, 37°C Homo sapiens
3.4.14.4 0.00651
-
 Arg-Arg-2-naphthylamide pH 7.4, 37°C Rattus norvegicus
3.4.14.4 0.00788
-
 Arg-Arg-2-naphthylamide pH 8.0, 37°C Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.14.4 Co2+ activation up to 2fold at micromolar concentrations Homo sapiens
3.4.14.4 Co2+ activation up to 50% at 0.001-0.0001 mM, inbhibitory above 0.002 mM Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.14.4 82500
-
 x * 82500, mass spectrometry Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.4 Homo sapiens
-
-
-
3.4.14.4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.14.4
-
 Homo sapiens
3.4.14.4
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.4 erythrocyte
-
 Homo sapiens
-
3.4.14.4 erythrocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.4 Ala-Ala-2-naphthylamide + H2O poor substrate Homo sapiens Ala-Ala + 2-naphthylamine
-
 ?
3.4.14.4 Ala-Ala-2-naphthylamide + H2O poor substrate Rattus norvegicus Ala-Ala + 2-naphthylamine
-
 ?
3.4.14.4 Arg-Arg-2-naphthylamide + H2O
-
 Homo sapiens Arg-Arg + 2-naphthylamine
-
 ?
3.4.14.4 Arg-Arg-2-naphthylamide + H2O
-
 Rattus norvegicus Arg-Arg + 2-naphthylamine
-
 ?
3.4.14.4 Lys-Ala-4-methoxy-2-naphthylamide + H2O poor substrate Homo sapiens Lys-Ala + 4-methoxy-2-naphthylamine
-
 ?
3.4.14.4 Lys-Ala-4-methoxy-2-naphthylamide + H2O poor substrate Rattus norvegicus Lys-Ala + 4-methoxy-2-naphthylamine
-
 ?
3.4.14.4 additional information enzyme prefers a hydrophobic residue at P1’ position Homo sapiens ?
-
 ?
3.4.14.4 additional information enzyme prefers a hydrophobic residue at P1’ position Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.14.4 ? x * 82500, mass spectrometry Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.14.4 7.4
-
 45% of maximal activity Homo sapiens
3.4.14.4 7.4
-
 45% of maximal activity Rattus norvegicus
3.4.14.4 8
-
-
 Rattus norvegicus
3.4.14.4 8
-
 80% of maximal activity Homo sapiens
3.4.14.4 8.7 8.8
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.14.4 0.000024
-
 angiotensin III 37°C, pH 7.4 Rattus norvegicus
3.4.14.4 0.00009
-
 angiotensin III 37°C, pH 7.4 Homo sapiens
3.4.14.4 0.00009
-
 Leu-Trp-Met-Arg-Phe 37°C, pH 7.4 Homo sapiens
3.4.14.4 0.00013
-
 Leu-Trp-Met-Arg-Phe 37°C, pH 7.4 Rattus norvegicus
3.4.14.4 0.00015
-
 Proctolin 37°C, pH 7.4 Homo sapiens
3.4.14.4 0.00021
-
 Lys-Val-Ile-Leu-Phe 37°C, pH 7.4 Homo sapiens
3.4.14.4 0.0004
-
 Lys-Val-Ile-Leu-Phe 37°C, pH 7.4 Rattus norvegicus
3.4.14.4 0.00043
-
 Proctolin 37°C, pH 7.4 Rattus norvegicus
3.4.14.4 0.00066
-
 angiotensin II 37°C, pH 7.4 Rattus norvegicus
3.4.14.4 0.00083
-
 angiotensin II 37°C, pH 7.4 Homo sapiens
3.4.14.4 0.0065
-
 His-Phe-Arg-Trp 37°C, pH 7.4 Homo sapiens
3.4.14.4 0.01
-
 His-Phe-Arg-Trp 37°C, pH 7.4 Rattus norvegicus
3.4.14.4 0.027
-
 Tyr-Gly-Gly-Phe-Leu 37°C, pH 7.4 Homo sapiens
3.4.14.4 0.027
-
 Tyr-Gly-Gly-Phe-Met 37°C, pH 7.4 Homo sapiens
3.4.14.4 0.0337
-
 Tyr-Gly-Gly-Phe-Leu 37°C, pH 7.4 Rattus norvegicus
3.4.14.4 0.0343
-
 Tyr-Gly-Gly-Phe-Met 37°C, pH 7.4 Rattus norvegicus
3.4.14.4 0.05
-
 Gly-Gly-Phe-Leu 37°C, pH 7.4 Homo sapiens
3.4.14.4 0.074
-
 Gly-Gly-Phe-Leu 37°C, pH 7.4 Rattus norvegicus