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Literature summary extracted from

  • Alunni, S.; Cipiciani, A.; Fioroni, G.; Ottavi, L.
    Mechanisms of inhibition of phenylalanine ammonia-lyase by phenol inhibitors and phenol/glycine synergistic inhibitors (2003), Arch. Biochem. Biophys., 412, 170-175.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.1.25 glycine 3.54 mM, 50% inhibition Rhodotorula glutinis
4.3.1.25 m-cresol 9.9 mM, 50% inhibition Rhodotorula glutinis
4.3.1.25 m-cresol/glycine 0.387 mM, 50% inhibition, strong synergistic inhibition Rhodotorula glutinis
4.3.1.25 additional information not inhibited by p-cresol Rhodotorula glutinis
4.3.1.25 o-Cresol 2.93 mM, 50% inhibition Rhodotorula glutinis
4.3.1.25 o-cresol/glycine 0.078 mM, 50% inhibition, strong synergistic inhibition Rhodotorula glutinis
4.3.1.25 p-cresol/glycine 1.03 mM, 50% inhibition Rhodotorula glutinis
4.3.1.25 phenol 3.89 mM, 50% inhibition Rhodotorula glutinis
4.3.1.25 phenol/glycine 0.056 mM 50% inhibition, strong synergistic inhibition Rhodotorula glutinis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.25 L-phenylalanine Rhodotorula glutinis
-
 (E)-cinnamate + NH3
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.25 Rhodotorula glutinis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.25 L-phenylalanine
-
 Rhodotorula glutinis (E)-cinnamate + NH3
-
 ?
4.3.1.25 L-phenylalanine
-
 Rhodotorula glutinis (E)-cinnamate + NH3
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.3.1.25 PAL
-
 Rhodotorula glutinis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.3.1.25 0.014
-
 phenol/glycine 25°C, pH 8.8 Rhodotorula glutinis
4.3.1.25 0.038
-
 o-cresol/glycine 25°C, pH 8.8 Rhodotorula glutinis
4.3.1.25 0.3
-
 m-cresol/glycine 25°C, pH 8.8 Rhodotorula glutinis
4.3.1.25 0.8
-
 o-Cresol 25°C, pH 8.8 Rhodotorula glutinis
4.3.1.25 1.2
-
 glycine 25°C, pH 8.8 Rhodotorula glutinis
4.3.1.25 2.1
-
 phenol 25°C, pH 8.8 Rhodotorula glutinis
4.3.1.25 2.85
-
 m-cresol 25°C, pH 8.8 Rhodotorula glutinis