Any feedback?
Literature summary extracted from
- Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes (1991), J. Biol. Chem., 266, 1375-1378.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.3.2.6 | medicine | the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.3.2.6 | bestatin | immediate and reversible effect on isolated enzyme | Homo sapiens |  |
| 3.3.2.6 | captopril | - |
Homo sapiens | |
| 3.3.2.6 | leukotriene A4 | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.3.2.6 | additional information | - |
additional information | - |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.3.2.6 | leukotriene A4 + H2O | Homo sapiens | biosynthesis of leukotriene B4 | leukotriene B4 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.3.2.6 | Homo sapiens | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.3.2.6 | erythrocyte | - |
Homo sapiens | - |
| 3.3.2.6 | neutrophil | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.3.2.6 | leukotriene A4 + H2O | - |
Homo sapiens | leukotriene B4 | - |
? | |
| 3.3.2.6 | leukotriene A4 + H2O | biosynthesis of leukotriene B4 | Homo sapiens | leukotriene B4 | - |
? | |
| 3.3.2.6 | lysine-4-nitroanilide + H2O | - |
Homo sapiens | lysine + 4-nitroaniline | - |
? | |
| 3.3.2.6 | additional information | - |
Homo sapiens | ? | - |
? | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.3.2.6 | 0.0002 | - |
bestatin | pH 8.0, 37°C | Homo sapiens | |
| 3.3.2.6 | 0.005 | - |
leukotriene A4 | pH 8.0, 37°C | Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
