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Literature summary extracted from

  • Konishi-Imamura, L.; Kim, D.H.; Koizumi, M.; Kobashi, K.
    Regulation of arylsulfate sulfotransferase from a human intestinal bacterium by nucleotides and magnesium ion (1995), J. Enzyme Inhib., 8, 233-241.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.22 ATP non-competitive, enzyme is not phosphorylated but binds ATP Eubacterium sp.
2.8.2.22 Cu2+ 50% inhibition at 0.6 mM Eubacterium sp.
2.8.2.22 diphosphate non-competitive Eubacterium sp.
2.8.2.22 nucleotide triphosphates non-competitive Eubacterium sp.
2.8.2.22 Pentachlorophenol 50% inhibition at 0.0255 mM with tyramine as substrate Eubacterium sp.
2.8.2.22 Zn2+ 99% inhibition at 0.6 mM Eubacterium sp.

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.8.2.22 Mg2+ 51% increase at 0.6 mM Eubacterium sp.
2.8.2.22 Mn2+ 23% increase at 0.6 mM Eubacterium sp.

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.22 Eubacterium sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.22 4-nitrophenyl sulfate + phenol
-
Eubacterium sp. phenyl sulfate + 4-nitrophenol
-
?
2.8.2.22 4-nitrophenyl sulfate + tyramine
-
Eubacterium sp. 4-(2-aminoethyl)phenyl sulfate + 4-nitrophenol
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.8.2.22 0.2
-
diphosphate for tyramine Eubacterium sp.
2.8.2.22 0.45
-
ATP for tyramine Eubacterium sp.
2.8.2.22 0.66
-
ATP for 4-nitrophenyl sulfate Eubacterium sp.
2.8.2.22 0.7
-
diphosphate for 4-nitrophenyl sulfate Eubacterium sp.