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Literature summary extracted from

  • Dubin, R.L.; Hall, C.M.; Pileri, C.L.; Kudlacek, P.E.; Li, X.Y.; Yee, J.A.; Johnson, M.L.; Anderson, R.J.
    Thermostable (SULT1A1) and thermolabile (SULT1A3) phenol sulfotransferases in human osteosarcoma and osteoblast cells (2001), Bone, 28, 617-624.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 2,6-Dichloro-4-nitrophenol SULT1A1 is more sensitive than SULT1A3 Homo sapiens
2.8.2.1 NaCl SULT1A1 is more sensitive than SULT1A3 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.1 0.00053
-
4-nitrophenol SULT1A1, pH 7.2, 37°C Homo sapiens
2.8.2.1 0.0071
-
dopamine SULT1A3, pH 6.5, 37°C Homo sapiens
2.8.2.1 0.047
-
3'-phosphoadenylylsulfate SULT1A1, pH 7.2, 37°C Homo sapiens
2.8.2.1 0.07
-
3'-phosphoadenylylsulfate SULT1A3, pH 6.5, 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 3'-phosphoadenylylsulfate + a phenol Homo sapiens sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds adenosine 3',5'-bisphosphate + an aryl sulfate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens
-
thermostable SULT1A1 and thermolabile SULT1A3
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 HOS-TE85 cell osteosarcoma cell line Homo sapiens
-
2.8.2.1 HOS-TE85 cell predominantly contains SULT1A3 activity Homo sapiens
-
2.8.2.1 osteosarcoma cell cell lines SaOS-2, U2-OS, PR, and HOS-TE85 Homo sapiens
-
2.8.2.1 osteosarcoma cell line predominantly contains SULT1A3 activity Homo sapiens
-
2.8.2.1 osteosarcoma cell line PR cell Homo sapiens
-
2.8.2.1 SAOS-2 cell osteosarcoma cell line Homo sapiens
-
2.8.2.1 SAOS-2 cell predominantly contains SULT1A1 activity Homo sapiens
-
2.8.2.1 U2-OS cell osteosarcoma cell line Homo sapiens
-
2.8.2.1 U2-OS cell predominantly contains SULT1A1 activity Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + a phenol
-
Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
?
2.8.2.1 3'-phosphoadenylylsulfate + 4-nitrophenol SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.1 3'-phosphoadenylylsulfate + a phenol sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
?
2.8.2.1 3'-phosphoadenylylsulfate + bisphenol A
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylylsulfate + dopamine SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.1 37
-
assay at Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.8.2.1 38.3
-
SULT1A3, 50% inactivation within 15 min Homo sapiens
2.8.2.1 43
-
SULT1A1, 50% inactivation within 15 min Homo sapiens
2.8.2.1 44
-
SULT1A3, inactivation within 15 min Homo sapiens
2.8.2.1 47
-
SULT1A1, inactivation within 15 min Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.1 6.5
-
SULT1A3 Homo sapiens
2.8.2.1 7.2
-
SULT1A1 Homo sapiens