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Literature summary extracted from

  • Dajani, R.; Cleasby, A.; Neu, M.; Wonacott, A.J.; Jhoti, H.; Hood, A.M.; Modi, S.; Hersey, A.; Taskinen, J.; Cooke, R.M.; Manchee, G.R.; Coughtrie, M.W.
    X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity (1999), J. Biol. Chem., 274, 37862-37868.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.8.2.1 complexed with adenosine 3',5'-bisphosphate, purified recombinant SULT1A3 at 10 mg/ml, sitting drop method at 20°C, protein solution: 50 mM Tris-HCl, pH 7.4, 1 mM 2-mercaptoethanol, 4 mM adenosine 3',5'-bisphosphate, precipitant solution: 0.65 M ammonium sulfate, 0.1 M sodium citrate, pH 5.1, 10 mM 2-mercaptoethanol, equal volumes, 4 days, X-ray diffraction structure determination and analysis Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.1 additional information
-
 additional information kinetics Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens P0DMM9 SULT1A3, is a M-PST enzyme form
-
2.8.2.1 Homo sapiens P50225 SULT1A1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + a phenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-chlorocatechol SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-chlorocatechol SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-chlorophenol SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + 4-chlorophenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-chlorophenol SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + 4-chlorophenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-isopropylcatechol SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-isopropylcatechol SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-methylcatechol SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-methylcatechol SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-methylphenol SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + 4-methylphenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-methylphenol SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + 4-methylphenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + catechol SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + catechol SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + dopamine SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + dopamine SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + phenol SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + phenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + phenol SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + phenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + tyramine SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + tyramine O-sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + tyramine SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + tyramine O-sulfate
-
 ?
2.8.2.1 additional information substrate specificity Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.1 37
-
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.1 6.8
-
 assay at Homo sapiens