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Literature summary extracted from

  • Benovic, J.L.; Strasser, R.H.; Caron, M.G.; Lefkowitz, R.J.
    beta-Adrenergic receptor kinase: Identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor (1986), Proc. Natl. Acad. Sci. USA, 83, 2797-2801.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.15 isoproterenol requirement, beta-agonist, beta-adrenergic receptor as substrate Mus musculus
2.7.11.15 isoproterenol requirement, beta-agonist, beta-adrenergic receptor as substrate Mesocricetus auratus
2.7.11.15 additional information not activated by cAMP, cGMP, Ca2+/calmodulin, Ca2+/phospholipid, phorbol esters Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.15 Alprenolol beta-adrenergic antagonist, blocks phosphorylation Mus musculus
2.7.11.15 additional information not inhibited by cAMP, cGMP, cAMP-dependent protein kinase inhibitor, Ca2+/calmodulin, Ca2+/phospholipid, phorbol esters Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.15 soluble predominantly Mus musculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.15 Mg2+ requirement Mus musculus
2.7.11.15 Mg2+ requirement Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor Mus musculus agonist-occupied form of the receptor ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor Mesocricetus auratus agonist-occupied form of the receptor ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor Mus musculus involved in homologous desensitization of beta-adrenergic receptor ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor Mesocricetus auratus involved in homologous desensitization of beta-adrenergic receptor ADP + phospho-beta-adrenergic receptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Mesocricetus auratus
-
 hamster
-
2.7.11.15 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.15 partial, 50-100fold, from kin- mutants of S49 lymphoma cells Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.15 brain
-
 Mus musculus
-
2.7.11.15 heart
-
 Mus musculus
-
2.7.11.15 heart
-
 Mesocricetus auratus
-
2.7.11.15 lung
-
 Mus musculus
-
2.7.11.15 S49 cell kin- mutant cell line of S49 lymphoma cells Mus musculus
-
2.7.11.15 smooth muscle
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Mus musculus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Mesocricetus auratus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor phosphate is incorporated solely into Ser-residues Mus musculus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor beta-AR from hamster lung Mus musculus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor agonist-occupied form of the receptor Mus musculus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor agonist-occupied form of the receptor Mesocricetus auratus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor involved in homologous desensitization of beta-adrenergic receptor Mus musculus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor involved in homologous desensitization of beta-adrenergic receptor Mesocricetus auratus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 additional information not: casein, histones Mus musculus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.15 30
-
 assay at Mus musculus
2.7.11.15 30
-
 assay at Mesocricetus auratus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.15 7.4
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.15 ATP
-
 Mus musculus
2.7.11.15 ATP
-
 Mesocricetus auratus