Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sekura, R.D.; Jakoby, W.B.
    Aryl sulfotransferase IV from rat liver (1981), Arch. Biochem. Biophys., 211, 352-359.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.9 KCl activates below 0.1 M, inhibits at higher concentrations Rattus norvegicus
2.8.2.9 NaCl activates below 0.1 M, inhibits at higher concentrations Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.9 0.1
-
 2-naphthol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.16
-
 dopamine pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.17
-
 4-nitrophenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.2
-
 3-methoxy-4-hydroxyphenylglycol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.21
-
 5-hydroxytryptophol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.26
-
 2-Chloro-4-nitrophenyl sulfate pH 7, 25°C Rattus norvegicus
2.8.2.9 0.34
-
 4-Chlorophenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.39 0.4 3-chlorophenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.43
-
 epinephrine pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.44
-
 3-Nitrophenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.46
-
 tyramine pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.91
-
 tyrosine methyl ester pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.92
-
 phenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 1.2
-
 4-Methylphenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 1.4
-
 4-methoxyphenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 1.5
-
 N-acetylserotonin pH 5.5, 37°C Rattus norvegicus
2.8.2.9 6.9
-
 2-cyanoethyl-N-hydroxythioacetamide pH 5.5, 37°C Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.8.2.9 KCl activates below 0.1 M, inhibits at higher concentrations Rattus norvegicus
2.8.2.9 NaCl activates below 0.1 M, inhibits at higher concentrations Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.9 33500
-
 2 * 33500, SDS-PAGE Rattus norvegicus
2.8.2.9 61000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.9 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.9
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.9 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.2.9 0.55
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.9 3'-phosphoadenylylsulfate + 2-chloro-4-nitrophenol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-chloro-4-nitrophenyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 2-cyanoethyl-N-hydroxythioacetamide
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 2-naphthol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 3-chlorophenol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 3-chlorophenyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 3-methoxy-4-hydroxyphenylglycol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 3-methylphenol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 3-methylphenyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 3-nitrophenol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 3-nitrophenyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 4-chlorophenol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-chlorophenyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 4-methoxyphenol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-methoxyphenyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 4-methylphenol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-methylphenyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 4-nitrophenol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 5-hydroxytryptophol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + dopamine
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + epinephrine
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + L-tyrosine methyl ester
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + methylphenol 3-methylphenol or 4-methylphenol Rattus norvegicus adenosine 3',5'-bisphosphate + methylphenyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + N-acetylserotonin
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + nitrophenol 3-nitrophenol or 4-nitrophenol Rattus norvegicus adenosine 3',5'-bisphosphate + nitrophenyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + phenol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + phenyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + tyramine
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.9 additional information catalyzes sulfate ester formation with simple phenols at an acidic pH and with several physiological metabolites at a more alkaline pH Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.8.2.9 dimer 2 * 33500, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.9 37
-
 assay at Rattus norvegicus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.8.2.9 0.02
-
 4-Methylphenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.0233
-
 2-cyanoethyl-N-hydroxythioacetamide pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.03
-
 phenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.0467
-
 tyramine pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.07
-
 dopamine pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.122
-
 epinephrine pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.14
-
 5-hydroxytryptophol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.183
-
 3-methylphenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.183
-
 3-methoxy-4-hydroxyphenolglycol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.233
-
 tyrosine methyl ester pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.3
-
 N-acetylserotonin pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.317
-
 4-Chlorophenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.45
-
 3-chlorophenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.45
-
 4-methoxyphenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.517
-
 4-nitrophenol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.7
-
 2-naphthol pH 5.5, 37°C Rattus norvegicus
2.8.2.9 0.8
-
 3-Nitrophenol pH 5.5, 37°C Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.9 5.5
-
 2-naphthol, sodium acetate buffer Rattus norvegicus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.8.2.9 Rattus norvegicus pH gradient from pH 3.5 to pH 10 in a linear sucrose gradient from 5% to 40%
-
 5.8