EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.21.99.4 | isoproterenol | type II | Rattus sp. | |
1.21.99.4 | additional information | hypothyroidism enhances type II activity and decreases type I activity | Rattus sp. |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.21.99.4 | translation of purified rat RNA in Xenopus laevis oocytes | Rattus sp. |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.21.99.4 | 6-Propyl-2-thiouracil | inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity | Rattus sp. | |
1.21.99.4 | ipanoic acid | type II | Rattus sp. | |
1.21.99.4 | propanolol | type II | Rattus sp. |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.21.99.4 | 0.001 | 0.005 | L-thyroxine | type II | Rattus sp. |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.21.99.4 | 3,3',5'-triiodothyronine + AH2 | Homo sapiens | - |
3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
1.21.99.4 | 3,3',5'-triiodothyronine + AH2 | Rattus sp. | isoenzyme type I | 3,3'-diiodothyronine + iodide + A + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.21.99.4 | Homo sapiens | - |
- |
- |
1.21.99.4 | Rattus sp. | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.21.99.4 | brain | thyronine 5'-deiodinase type II | Rattus sp. | - |
1.21.99.4 | brown adipose tissue | thyronine 5'-deiodinase type II | Rattus sp. | - |
1.21.99.4 | harderian gland | thyronine 5'-deiodinase type II | Rattus sp. | - |
1.21.99.4 | hypophysis | thyronine 5'-deiodinase type II | Rattus sp. | - |
1.21.99.4 | keratinocyte | thyronine 5'-deiodinase type II | Rattus sp. | - |
1.21.99.4 | kidney | - |
Rattus sp. | - |
1.21.99.4 | liver | - |
Homo sapiens | - |
1.21.99.4 | liver | thyronine 5'-deiodinase type I | Rattus sp. | - |
1.21.99.4 | pineal gland | thyronine 5'-deiodinase type II | Rattus sp. | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.21.99.4 | 3,3',5'-triiodothyronine + AH2 | - |
Homo sapiens | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
1.21.99.4 | 3,3',5'-triiodothyronine + AH2 | isoenzyme type I | Rattus sp. | 3,3'-diiodothyronine + iodide + A + H+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.21.99.4 | iodothyronine 5'-deiodinase | type II, no selenoprotein, induced by bt2cAMP and hydrocortisone (ED50 4nM) | Rattus sp. |