EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
6.2.1.1 | acetate | required for ATP-diphosphate exchange | Bos taurus |
EC Number | General Stability | Organism |
---|---|---|
6.2.1.1 | photoinactivation in presence of methylene blue | Oryctolagus cuniculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
6.2.1.1 | seleno-CoA | competitive to CoA | Bos taurus | |
6.2.1.10 | F- | 2 mM, complete inhibition | Rattus norvegicus | |
6.2.1.10 | phosphate | 5 mM, 70% inhibition | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
6.2.1.1 | 0.017 | - |
ATP | in Tris buffer, pH 6.7, 200 mM K+ | Bos taurus | |
6.2.1.1 | 0.1 | - |
ATP | in Pipes buffer, pH 6.7, 200 mM K+ | Bos taurus | |
6.2.1.1 | 0.14 | - |
acetate | pH 6.7, 200 mM K+ | Bos taurus | |
6.2.1.1 | 0.21 | - |
CoA | - |
Bos taurus | |
6.2.1.1 | 0.22 | - |
acetate | CoA, in Tris buffer, pH 8.3, 200 mM K+ | Bos taurus | |
6.2.1.1 | 0.28 | - |
CoA | in Tris buffer, pH 6.7, 200 mM K+ | Bos taurus | |
6.2.1.1 | 0.35 | - |
ATP | Tris buffer, pH 8.3, 200 mM K+ | Bos taurus | |
6.2.1.1 | 0.65 | - |
acetate | - |
Bos taurus | |
6.2.1.1 | 0.71 | - |
ATP | - |
Bos taurus | |
6.2.1.1 | 1.2 | - |
CoA | in Pipes buffer, pH 6.7, 200 mM K+ | Bos taurus | |
6.2.1.10 | 0.2 | - |
Octanoate | - |
Rattus norvegicus | |
6.2.1.10 | 0.22 | - |
Butyrate | - |
Rattus norvegicus | |
6.2.1.10 | 2.1 | - |
oleate | - |
Rattus norvegicus | |
6.2.1.10 | 3.3 | - |
CoA | - |
Rattus norvegicus | |
6.2.1.10 | 3.3 | - |
palmitate | - |
Rattus norvegicus | |
6.2.1.10 | 4.3 | - |
GTP | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
6.2.1.10 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
6.2.1.1 | Ca2+ | two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding | Bos taurus | |
6.2.1.1 | Cd2+ | two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding | Bos taurus | |
6.2.1.1 | Co2+ | two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding | Bos taurus | |
6.2.1.1 | Cu2+ | two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding | Bos taurus | |
6.2.1.1 | Fe2+ | two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding | Bos taurus | |
6.2.1.1 | K+ | activates, absolute requirement for certain monovalent cations, no inhibition at high concentrations | Bos taurus | |
6.2.1.1 | Li+ | activation at 5-8 mM, absolute requirement for certain monovalent cations, inhibition above 10 mM | Bos taurus | |
6.2.1.1 | Mg2+ | required | Bos taurus | |
6.2.1.1 | Mg2+ | two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding | Bos taurus | |
6.2.1.1 | Mn2+ | two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding | Bos taurus | |
6.2.1.1 | Na+ | activation at 5-8 mM, absolute requirement for certain monovalent cations, inhibition above 10 mM | Bos taurus | |
6.2.1.1 | NH4+ | activates, absolute requirement for certain monovalent cations, no inhibition at high concentrations | Bos taurus | |
6.2.1.1 | Ni2+ | two types of divalent metal ion requirement, 1. Mg2+, Mn2+, Fe2+, Co2+ or Ca2+ required for the formation of the enzyme-bound acetyl adenylate, 2. Ni2+, Cd2+, Fe2+ or Cu2+ required for adenylate binding | Bos taurus | |
6.2.1.1 | Rb+ | activates, absolute requirement for certain monovalent cations, no inhibition at high concentrations | Bos taurus | |
6.2.1.1 | Tris | activates, absolute requirement for certain monovalent cations, no inhibition at high concentrations | Bos taurus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
6.2.1.10 | 20000 | - |
gel filtration | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.2.1.1 | Aspergillus niger | - |
- |
- |
6.2.1.1 | Bos taurus | - |
- |
- |
6.2.1.1 | Euglena gracilis | - |
- |
- |
6.2.1.1 | Oryctolagus cuniculus | - |
- |
- |
6.2.1.1 | Rattus norvegicus | - |
- |
- |
6.2.1.10 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
6.2.1.1 | adipose tissue | - |
Rattus norvegicus | - |
6.2.1.1 | brain | - |
Rattus norvegicus | - |
6.2.1.1 | brain | - |
Bos taurus | - |
6.2.1.1 | heart | - |
Rattus norvegicus | - |
6.2.1.1 | heart | - |
Bos taurus | - |
6.2.1.1 | liver | - |
Rattus norvegicus | - |
6.2.1.1 | liver | - |
Oryctolagus cuniculus | - |
6.2.1.10 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.2.1.1 | ATP + acetate + CoA | - |
Rattus norvegicus | AMP + diphosphate + acetyl-CoA | - |
? | |
6.2.1.1 | ATP + acetate + CoA | - |
Oryctolagus cuniculus | AMP + diphosphate + acetyl-CoA | - |
? | |
6.2.1.1 | ATP + acetate + CoA | - |
Euglena gracilis | AMP + diphosphate + acetyl-CoA | - |
? | |
6.2.1.1 | ATP + acetate + CoA | - |
Aspergillus niger | AMP + diphosphate + acetyl-CoA | - |
? | |
6.2.1.1 | ATP + acetate + CoA | neither glutathione nor pantetheine can substitute for CoA as acyl acceptor | Bos taurus | AMP + diphosphate + acetyl-CoA | - |
? | |
6.2.1.1 | ATP + acetate + seleno-CoA | - |
Bos taurus | AMP + diphosphate + acetyl-seleno-CoA | - |
? | |
6.2.1.1 | ATP + acrylate + CoA | - |
Bos taurus | AMP + diphosphate + acryloyl-CoA | - |
? | |
6.2.1.1 | ATP + butyrate + CoA | isobutyrate | Bos taurus | AMP + diphosphate + butyryl-CoA | - |
? | |
6.2.1.1 | ATP + fluoroacetate + CoA | - |
Bos taurus | AMP + diphosphate + fluoroacetyl-CoA | - |
? | |
6.2.1.1 | ATP + propanoate + CoA | - |
Bos taurus | AMP + diphosphate + propanoyl-CoA | - |
? | |
6.2.1.1 | dATP + acetate + CoA | 70% of the activity relative to ATP | Bos taurus | dAMP + diphosphate + acetyl-CoA | - |
? | |
6.2.1.1 | additional information | - |
Oryctolagus cuniculus | ? | - |
? | |
6.2.1.1 | additional information | enzyme catalyzes acetate-dependent ATP-diphosphate exchange | Bos taurus | ? | - |
? | |
6.2.1.10 | GTP + butyrate + CoA | - |
Rattus norvegicus | GDP + phosphate + butyryl-CoA | - |
? | |
6.2.1.10 | GTP + octanoate + CoA | - |
Rattus norvegicus | GDP + phosphate + octanoyl-CoA | - |
? | |
6.2.1.10 | GTP + oleate + CoA | - |
Rattus norvegicus | GDP + phosphate + oleoyl-CoA | - |
? | |
6.2.1.10 | GTP + palmitate + CoA | - |
Rattus norvegicus | GDP + phosphate + palmitoyl-CoA | - |
? | |
6.2.1.10 | additional information | the different specificity of the isolated GTP-dependent enzymes for fatty acid substrates results from their different lecithin contents | Rattus norvegicus | ? | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
6.2.1.1 | 8 | - |
ATP-diphosphate exchange | Bos taurus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.2.1.10 | 4'-phosphopantetheine | contains 1 M 4ยด-phosphopantetheine per 20000 g enzyme | Rattus norvegicus |