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Literature summary extracted from

  • Chuang, T.T.; Sallese, M.; Ambrosini, G.; Parruti, G.; De Blasi, A.
    High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation (1992), J. Biol. Chem., 267, 6886-6892.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.15 isoproterenol requirement, beta-agonist, beta-adrenergic receptor as substrate Homo sapiens
2.7.11.15 isoproterenol requirement, beta-agonist, beta-adrenergic receptor as substrate Bos taurus
2.7.11.15 platelet activating factor requirement, agonist, beta-adrenergic receptor as substrate Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.15 cDNA encoding beta-ARK 1 is cloned and sequenced, very similar sequences of bovine and human kinases Homo sapiens
2.7.11.15 cloning and sequencing Homo sapiens
2.7.11.15 very similar cDNA sequences of bovine and human kinases Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.15 heparin
-
 Bos taurus
2.7.11.15 heparin rhodopsin phosphorylation, in a dose-dependent manner Homo sapiens
2.7.11.15 additional information
-
 Bos taurus
2.7.11.15 additional information not inhibited by protein kinase A inhibitor PKI; not inhibited by staurosporine Homo sapiens
2.7.11.15 Protein kinase C inhibitor H7 weak Bos taurus
2.7.11.15 Protein kinase C inhibitor H7 weak Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.15 cytosol
-
 Bos taurus 5829
-
2.7.11.15 cytosol cytosolic enzyme, isoproterenol and platelet-activating factor induce translocation of beta-ARK from cytosol to membrane Homo sapiens 5829
-
2.7.11.15 membrane
-
 Bos taurus 16020
-
2.7.11.15 membrane isoproterenol and platelet-activating factor induce translocation of beta-ARK from cytosol to membrane Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.15 Mg2+ requirement Homo sapiens
2.7.11.15 Mg2+ requirement Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor Homo sapiens presumably modulates some receptor-mediated immune functions ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor Homo sapiens agonist-occupied form of the receptor ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor Bos taurus agonist-occupied form of the receptor ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor Homo sapiens involved in homologous desensitization of beta-adrenergic receptor ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor Bos taurus involved in homologous desensitization of beta-adrenergic receptor ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 additional information Homo sapiens role for beta ARK in modulating some receptor-mediated immune functions ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Bos taurus
-
 enzyme exists in 2 subtypes: beta-ARK 1 and beta-ARK 2
-
2.7.11.15 Homo sapiens
-
 major isoform beta-ARK 1
-
2.7.11.15 Homo sapiens
-
 enzyme exists in 2 subtypes: beta-ARK1 and 2
-
2.7.11.15 Homo sapiens P25098
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.15 heart moderate expression of beta-ARK 1 Homo sapiens
-
2.7.11.15 HL-60 cell high expression of beta-ARK 1 Homo sapiens
-
2.7.11.15 IMR-32 cell beta-ARK 1 Homo sapiens
-
2.7.11.15 JURKAT cell high expression of beta-ARK 1 Homo sapiens
-
2.7.11.15 leukemia cell myeloid and lymphoid leukemia cell lines, high expression of beta-ARK 1 Homo sapiens
-
2.7.11.15 leukocyte
-
 Bos taurus
-
2.7.11.15 leukocyte peripheral blood leukocytes Homo sapiens
-
2.7.11.15 leukocyte mononuclear, peripheral blood leukocytes, high expression Homo sapiens
-
2.7.11.15 leukocyte beta-ARK 1 Homo sapiens
-
2.7.11.15 MOLT-4 cell high expression of beta-ARK 1 Homo sapiens
-
2.7.11.15 additional information
-
 Bos taurus
-
2.7.11.15 additional information tissue distribution of beta-ARK 1 Homo sapiens
-
2.7.11.15 U-937 cell high expression of beta-ARK 1 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Homo sapiens ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor presumably modulates some receptor-mediated immune functions Homo sapiens ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor agonist-occupied form of the receptor Homo sapiens ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor agonist-occupied form of the receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor involved in homologous desensitization of beta-adrenergic receptor Homo sapiens ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor involved in homologous desensitization of beta-adrenergic receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + platelet-activating factor receptor PAF receptor acts as substrate Homo sapiens ADP + phospho-platelet-activating factor receptor
-
 ?
2.7.11.15 ATP + rhodopsin light-dependent, actual substrate: light-bleached rhodopsin Homo sapiens ADP + phosphorhodopsin
-
 ?
2.7.11.15 ATP + rhodopsin light-dependent, actual substrate: light-bleached rhodopsin Bos taurus ADP + phosphorhodopsin
-
 ?
2.7.11.15 ATP + rhodopsin in form of bovine rod outer segments Homo sapiens ADP + phosphorhodopsin
-
 ?
2.7.11.15 ATP + rhodopsin in form of bovine rod outer segments Bos taurus ADP + phosphorhodopsin
-
 ?
2.7.11.15 additional information role for beta ARK in modulating some receptor-mediated immune functions Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.15 ark
-
 Homo sapiens
2.7.11.15 beta-adrenergic receptor kinase 1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.15 30
-
 assay at Homo sapiens
2.7.11.15 30
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.15 7.4
-
 assay at Homo sapiens
2.7.11.15 7.4
-
 assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.15 ATP
-
 Homo sapiens
2.7.11.15 ATP
-
 Bos taurus