Literature summary extracted from

Agnew, W.S.; Popjak, G.
Squalene synthetase. Solubilization from yeast microsomes of a phospholipid-requiring enzyme (1978), J. Biol. Chem., 253, 4574-4583.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.5.1.21	additional information	absolute requirement for phospholipid	Saccharomyces cerevisiae

General Stability

EC Number	General Stability	Organism
2.5.1.21	NADPH has no effect on stability	Saccharomyces cerevisiae

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.5.1.21	deoxycholate	-	Saccharomyces cerevisiae

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.5.1.21	microsome	-	Saccharomyces cerevisiae	-	-

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
2.5.1.21	54500	-	gel filtration, sucrose density gradient sedimentation	Saccharomyces cerevisiae

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.21	Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.21	farnesyl diphosphate + NAD(P)H	-	Saccharomyces cerevisiae	squalene + diphosphate + NAD(P)+	-	?

Temperature Stability [°C]

EC Number	Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
2.5.1.21	25	-	in presence of deoxycholate, 5 min, 50% loss of activity	Saccharomyces cerevisiae
2.5.1.21	41	-	without deoxycholate, 5 min, 50% loss of activity	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)