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Literature summary extracted from

  • Nishino, T.; Katsuki, H.
    Formation of 12-cis-dehydrosqualene catalyzed by squalene synthetase (1985), Methods Enzymol., 110, 373-375.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.21 microsome
-
Saccharomyces cerevisiae
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.21 Mg2+ most effective in stimulation of squalene formation, half-maximal activity at 2.5 mM Saccharomyces cerevisiae
2.5.1.21 Mg2+ Mn2+ is more effective than Mg2+ in activation of dehydrosqualene formation Saccharomyces cerevisiae
2.5.1.21 Mn2+ more effective than Mg2+ in activation of dehydrosqualene formation Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.21 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.21 farnesyl diphosphate in presence of Mn2+ Saccharomyces cerevisiae 12,13-cis-dehydrosqualene + diphosphate 12-cis-dehydrosqualene + diphosphate ?
2.5.1.21 farnesyl diphosphate + NAD(P)H
-
Saccharomyces cerevisiae squalene + diphosphate + NAD(P)+
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.21 NADPH
-
Saccharomyces cerevisiae