EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.3.2.2 | Free bile acids | activation | Rattus norvegicus | |
2.3.2.2 | Free bile acids | activation | Sus scrofa | |
2.3.2.2 | Maleate | - |
Rattus norvegicus | |
2.3.2.2 | Maleate | - |
Sus scrofa |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.2.2 | L- or D-Serine/borate | - |
Rattus norvegicus | |
2.3.2.2 | L- or D-Serine/borate | transition-state inhibitor | Sus scrofa | |
2.3.2.2 | L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazolacetic acid | i.e. acivicin; strong, irreversible, reacts with glutamyl binding site | Sus scrofa | |
2.3.2.2 | Phenobarbital | - |
Rattus norvegicus | |
2.3.2.2 | Phenobarbital | - |
Sus scrofa | |
2.3.2.2 | Thiobarbituric acid | - |
Rattus norvegicus | |
2.3.2.2 | Thiobarbituric acid | - |
Sus scrofa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.2.2 | additional information | - |
additional information | kinetic study | Rattus norvegicus | |
2.3.2.2 | additional information | - |
additional information | kinetic study | Sus scrofa |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.2.2 | membrane | - |
Rattus norvegicus | 16020 | - |
2.3.2.2 | membrane | - |
Sus scrofa | 16020 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.2.2 | Rattus norvegicus | - |
- |
- |
2.3.2.2 | Sus scrofa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.2.2 | - |
Sus scrofa |
2.3.2.2 | papain | Rattus norvegicus |
2.3.2.2 | Triton X-100 | Rattus norvegicus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.3.2.2 | a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid | mechanism | Rattus norvegicus | |
2.3.2.2 | a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid | mechanism | Sus scrofa | |
2.3.2.2 | a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid | kinetic study | Rattus norvegicus | |
2.3.2.2 | a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid | kinetic study | Sus scrofa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.2.2 | kidney | - |
Rattus norvegicus | - |
2.3.2.2 | kidney | - |
Sus scrofa | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.2.2 | 792 | - |
purified enzyme | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | donors: 5-ethyl-Glu and beta-benzyl-Glu, hydrolyzed by pig enzyme | Sus scrofa | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | donors: ophthalmic acid, poly-5-Glu-derivatives, L-5-Glu-7-amino-4-methylcoumarin | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | donors: ophthalmic acid, poly-5-Glu-derivatives, L-5-Glu-7-amino-4-methylcoumarin | Sus scrofa | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | donor: leukotriene C | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | donor: leukotriene C | Sus scrofa | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | Glu-donor is GSH | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | Glu-donor is GSH | Sus scrofa | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | donor: glutathione disulfide | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | donor: glutathione disulfide | Sus scrofa | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | donor: S-acetophenoneglutathione | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | (5-L-glutamyl)-peptide + acceptor + H+ | donor: S-acetophenoneglutathione | Sus scrofa | peptide + 5-L-glutamyl amino acid | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + L-cystine | best acceptor | Rattus norvegicus | 4-nitroaniline + 5-L-glutamyl-L-cystine | - |
? | |
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + L-cystine | best acceptor | Sus scrofa | 4-nitroaniline + 5-L-glutamyl-L-cystine | - |
? | |
2.3.2.2 | 5-L-glutamyl-7-amido-4-methylcoumarin + glycylglycine | - |
Rattus norvegicus | 7-amino-4-methylcoumarin + 5-L-glutamyl-glycylglycine | - |
? | |
2.3.2.2 | 5-L-glutamyl-7-amido-4-methylcoumarin + glycylglycine | - |
Sus scrofa | 7-amino-4-methylcoumarin + 5-L-glutamyl-glycylglycine | - |
? | |
2.3.2.2 | glutathione + acceptor | best donor | Rattus norvegicus | cysteinylglycine + 5-L-glutamyl-acceptor | - |
? | |
2.3.2.2 | glutathione + acceptor | best donor | Sus scrofa | cysteinylglycine + 5-L-glutamyl-acceptor | - |
? | |
2.3.2.2 | glutathione + leukotriene D | - |
Sus scrofa | cysteinylglycine + leukotriene C | - |
? | |
2.3.2.2 | leukotriene C4 + acceptor | i.e. glutathione containing derivative of arachidonic acid, acceptors are H2O, amino acids or dipeptides | Rattus norvegicus | leukotriene D4 + glutamyl-acceptor | - |
? | |
2.3.2.2 | leukotriene C4 + acceptor | i.e. glutathione containing derivative of arachidonic acid, acceptors are H2O, amino acids or dipeptides | Sus scrofa | leukotriene D4 + glutamyl-acceptor | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.2.2 | 37 | - |
assay at | Rattus norvegicus |
2.3.2.2 | 37 | - |
assay at | Sus scrofa |