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Literature summary extracted from

  • Axelrod, J.; Daly, J.
    Phenol-O-methyltransferase (1968), Biochim. Biophys. Acta, 159, 472-478.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.25 Mg2+ 10 mM, 61% inhibition Cavia porcellus
2.1.1.25 NEM 0.1 mM, 90% inhibition Cavia porcellus
2.1.1.25 PCMB 0.01 mM, 85% inhibition Cavia porcellus
2.1.1.25 SKF 525 0.5 mM, 56% inhibition Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.25 microsome
-
 Cavia porcellus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.25 Cavia porcellus
-
-
-
2.1.1.25 Mus musculus
-
-
-
2.1.1.25 Oryctolagus cuniculus
-
-
-
2.1.1.25 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.25 adrenal gland low activity Cavia porcellus
-
2.1.1.25 gut low activity Cavia porcellus
-
2.1.1.25 kidney
-
 Cavia porcellus
-
2.1.1.25 liver
-
 Cavia porcellus
-
2.1.1.25 liver
-
 Oryctolagus cuniculus
-
2.1.1.25 lung
-
 Cavia porcellus
-
2.1.1.25 spleen low activity Cavia porcellus
-
2.1.1.25 testis low activity Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.25 S-adenosyl-L-methionine + m-bromophenol
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + m-bromoanisole
-
 ?
2.1.1.25 S-adenosyl-L-methionine + m-chlorophenol
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + m-chloroanisole
-
 ?
2.1.1.25 S-adenosyl-L-methionine + m-methoxyphenol
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + 1,3-dimethoxybenzene
-
 ?
2.1.1.25 S-adenosyl-L-methionine + m-nitrophenol
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + m-nitroanisole
-
 ?
2.1.1.25 S-adenosyl-L-methionine + o-chlorophenol
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + o-chloroanisole
-
 ?
2.1.1.25 S-adenosyl-L-methionine + o-methoxyphenol
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + veratrole
-
 ?
2.1.1.25 S-adenosyl-L-methionine + o-methylphenol
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + o-methylanisole
-
 ?
2.1.1.25 S-adenosyl-L-methionine + p-chlorophenol
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + p-chloroanisole
-
 ?
2.1.1.25 S-adenosyl-L-methionine + p-ethylphenol
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + p-ethylanisole
-
 ?
2.1.1.25 S-adenosyl-L-methionine + p-hydroxyacetanilide
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + p-methoxyacetanilide
-
 ?
2.1.1.25 S-adenosyl-L-methionine + p-methoxyphenol
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + 1,4-dimethoxybenzene
-
 ?
2.1.1.25 S-adenosyl-L-methionine + p-methylphenol
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + p-methylanisole
-
 ?
2.1.1.25 S-adenosyl-L-methionine + phenol
-
 Cavia porcellus S-adenosyl-L-homocysteine + anisole
-
 ?
2.1.1.25 S-adenosyl-L-methionine + phenol
-
 Mus musculus S-adenosyl-L-homocysteine + anisole
-
 ?
2.1.1.25 S-adenosyl-L-methionine + phenol
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + anisole
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.25 7.6 8.3
-
 Cavia porcellus