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Literature summary extracted from
- Characterization and partial purification of squalene-hopene cyclase from Bacillus acidocaldarius (1986), Biochim. Biophys. Acta, 881, 356-363.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.4.99.17 | (5-hydroxycarvacryl)trimethylammonium chloride 1-piperidine carboxylate | 99% inhibition at 1 mM | Alicyclobacillus acidocaldarius |  |
| 5.4.99.17 | diethyldicarbonate | 92% inhibition at 5 mM | Alicyclobacillus acidocaldarius | |
| 5.4.99.17 | N-ethylmaleimide | 65% inhibition at 5 mM, 20% inhibition at 1 mM | Alicyclobacillus acidocaldarius | |
| 5.4.99.17 | p-chloromercuribenzenesulfonic acid | 96% inhibition at 1 mM | Alicyclobacillus acidocaldarius | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.4.99.17 | 0.003 | - |
squalene | - |
Alicyclobacillus acidocaldarius | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.4.99.17 | membrane | - |
Alicyclobacillus acidocaldarius | 16020 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.4.99.17 | 75000 | - |
SDS-PAGE | Alicyclobacillus acidocaldarius |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.4.99.17 | Alicyclobacillus acidocaldarius | - |
- |
- |
| 5.4.99.17 | Alicyclobacillus acidocaldarius 104-IA | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.4.99.17 | - |
Alicyclobacillus acidocaldarius |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.17 | squalene | products are formed in a molar ratio of hopene:hopanol, 5:1 | Alicyclobacillus acidocaldarius | hop-22(29)-ene | - |
? | |
| 5.4.99.17 | squalene | products are formed in a molar ratio of hopene:hopanol, 5:1 | Alicyclobacillus acidocaldarius 104-IA | hop-22(29)-ene | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 5.4.99.17 | 60 | - |
- |
Alicyclobacillus acidocaldarius |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.4.99.17 | 6 | - |
- |
Alicyclobacillus acidocaldarius |
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