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Literature summary extracted from
- In situ and in vitro kinetics of phenol hydroxylase (1987), Biochem. Biophys. Res. Commun., 146, 41-46.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.7 | PEG 400 | slight increase | Cutaneotrichosporon cutaneum |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.7 | 2-Fluorophenol | substrate inhibition | Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | 3-chlorophenol | substrate inhibition | Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | 3-Fluorophenol | substrate inhibition | Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | 4-Chlorophenol | substrate inhibition | Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | 4-Fluorophenol | substrate inhibition | Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | catechol | substrate inhibition | Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | phenol | substrate inhibition | Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | resorcinol | substrate inhibition | Cutaneotrichosporon cutaneum | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.13.7 | additional information | - |
additional information | Km value is 6-20times higher when phenol derivative is added before NADPH | Cutaneotrichosporon cutaneum |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.7 | Cutaneotrichosporon cutaneum | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.7 | 2-fluorophenol + O2 + NADPH | - |
Cutaneotrichosporon cutaneum | ? | - |
? | |
| 1.14.13.7 | 3-chlorophenol + O2 + NADPH | - |
Cutaneotrichosporon cutaneum | ? | - |
? | |
| 1.14.13.7 | 3-fluorophenol + O2 + NADPH | - |
Cutaneotrichosporon cutaneum | ? | - |
? | |
| 1.14.13.7 | 3-methylphenol + O2 + NADPH | - |
Cutaneotrichosporon cutaneum | ? | - |
? | |
| 1.14.13.7 | 4-chlorophenol + O2 + NADPH | - |
Cutaneotrichosporon cutaneum | ? | - |
? | |
| 1.14.13.7 | 4-fluorophenol + O2 + NADPH | - |
Cutaneotrichosporon cutaneum | ? | - |
? | |
| 1.14.13.7 | 4-methyl-phenol + O2 + NADPH | - |
Cutaneotrichosporon cutaneum | ? | - |
? | |
| 1.14.13.7 | catechol + O2 + NADPH | - |
Cutaneotrichosporon cutaneum | ? | - |
? | |
| 1.14.13.7 | phenol + NADPH + O2 | - |
Cutaneotrichosporon cutaneum | catechol + NADP+ + H2O | - |
? | |
| 1.14.13.7 | resorcinol + NADPH + O2 | - |
Cutaneotrichosporon cutaneum | ? | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.7 | NADPH | - |
Cutaneotrichosporon cutaneum | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.13.7 | 0.72 | - |
phenol | - |
Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | 1.8 | - |
resorcinol | - |
Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | 2.3 | - |
3-chlorophenol | - |
Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | 2.3 | - |
4-Fluorophenol | - |
Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | 2.6 | - |
4-Chlorophenol | - |
Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | 6.3 | - |
3-Fluorophenol | - |
Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | 12.5 | - |
catechol | - |
Cutaneotrichosporon cutaneum | |
| 1.14.13.7 | 30.8 | - |
2-Fluorophenol | - |
Cutaneotrichosporon cutaneum | |
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