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Literature summary extracted from

  • Favre, B.; Ryder, N.S.
    Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents (1996), Antimicrob. Agents Chemother., 40, 443-447.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.17 Mega-9 0.3%, 44% activation Trichophyton rubrum
1.14.14.17 octyl beta-D-glucopyranoside 0.3%, 42% activation Trichophyton rubrum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.17 amorolfine 0.03 mM, 50% inhibition Trichophyton rubrum
1.14.14.17 Mega-8 0.3%, 19% inhibition Trichophyton rubrum
1.14.14.17 additional information strong inhibition by allylamines Trichophyton rubrum
1.14.14.17 SDZ 87-469 0.000020 mM, 50% inhibition Trichophyton rubrum
1.14.14.17 terbinafine 0.0000158 mM, 50% inhibition, non-competitive vs. squalene Trichophyton rubrum
1.14.14.17 tolciclate 0.000028 mM, 50% inhibition Trichophyton rubrum
1.14.14.17 tolnaftate 0.0000515 mM, 50% inhibition Trichophyton rubrum
1.14.14.17 Triton X-100 0.3%, 71% inhibition Trichophyton rubrum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.17 0.0133
-
 squalene
-
 Trichophyton rubrum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.17 microsome
-
 Trichophyton rubrum
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.17 Trichophyton rubrum
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.14.17 0.000012
-
 activity in microsomes Trichophyton rubrum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.17 squalene + NAD(P)H + O2 NADPH is slightly preferred Trichophyton rubrum (S)-squalene-2,3-epoxide + NADP+ + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.17 additional information FAD stimulates activity but is not essential Trichophyton rubrum