EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.17 | (E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride | i.e. compound SF 86-327, non-competitive inhibition | Candida albicans | |
1.14.14.17 | (E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride | i.e. compound SF 86-327, non-competitive inhibition | Candida parapsilosis | |
1.14.14.17 | (E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride | i.e. compound SF 86-327, non-competitive inhibition | Rattus norvegicus | |
1.14.14.17 | (E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine | i.e. naftifine, non-competitive inhibition | Candida albicans | |
1.14.14.17 | (E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine | i.e. naftifine, non-competitive inhibition | Candida parapsilosis | |
1.14.14.17 | (E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine | i.e. naftifine, non-competitive inhibition | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.14.17 | 0.011 | - |
squalene | - |
Rattus norvegicus | |
1.14.14.17 | 0.016 | - |
squalene | - |
Candida parapsilosis | |
1.14.14.17 | 0.05 | - |
squalene | - |
Candida albicans |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.17 | Candida albicans | - |
- |
- |
1.14.14.17 | Candida parapsilosis | - |
- |
- |
1.14.14.17 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.17 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.17 | squalene + NAD(P)H + O2 | NADPH is preferred | Rattus norvegicus | (S)-squalene-2,3-epoxide + NADP+ + H2O | - |
? | |
1.14.14.17 | squalene + NAD(P)H + O2 | NADH is preferred | Candida albicans | (S)-squalene-2,3-epoxide + NADP+ + H2O | - |
? | |
1.14.14.17 | squalene + NAD(P)H + O2 | NADH is preferred | Candida parapsilosis | (S)-squalene-2,3-epoxide + NADP+ + H2O | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.17 | FAD | required for activity | Rattus norvegicus | |
1.14.14.17 | FAD | required for activity | Candida albicans | |
1.14.14.17 | FAD | required for activity | Candida parapsilosis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.14.17 | 0.00003 | - |
(E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride | - |
Candida albicans | |
1.14.14.17 | 0.00004 | - |
(E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride | - |
Candida parapsilosis | |
1.14.14.17 | 0.00034 | - |
(E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine | - |
Candida parapsilosis | |
1.14.14.17 | 0.0011 | - |
(E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine | - |
Candida albicans | |
1.14.14.17 | 0.077 | - |
(E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride | - |
Rattus norvegicus | |
1.14.14.17 | 1.44 | - |
(E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine | - |
Rattus norvegicus |