EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.14.17 | 0.00043 | - |
FAD | - |
Rattus norvegicus | |
1.14.14.17 | 0.00085 | - |
1-carba-1-deaza-FAD | - |
Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.17 | squalene + electron donor + O2 | Rattus norvegicus | first oxygenase and last nonsterol reaction of sterol biosynthesis | (S)-squalene-2,3-epoxide + oxidized electron donor + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.17 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.14.14.17 | partial | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.17 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.17 | (3S)-2,3-epoxy-2,3-dihydrosqualene + 1-carba-1-deaza-FAD + H2O | - |
Rattus norvegicus | squalene + 1-carba-1-deaza-FADH2 + O2 | - |
r | |
1.14.14.17 | (3S)-2,3-epoxy-2,3-dihydrosqualene + FAD + H2O | - |
Rattus norvegicus | squalene + FADH2 + O2 | - |
r | |
1.14.14.17 | squalene + electron donor + O2 | first oxygenase and last nonsterol reaction of sterol biosynthesis | Rattus norvegicus | (S)-squalene-2,3-epoxide + oxidized electron donor + H2O | - |
? | |
1.14.14.17 | squalene + NAD(P)H + O2 | - |
Rattus norvegicus | (S)-squalene-2,3-epoxide + NADP+ + H2O | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.17 | 1-Carba-1-deazaFAD | can replace FAD as cofactor | Rattus norvegicus | |
1.14.14.17 | FAD | flavoprotein | Rattus norvegicus | |
1.14.14.17 | additional information | 5-carba-5-deazaFAD cannot replace FAD as cofactor | Rattus norvegicus |