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Literature summary extracted from

  • Hada, T.; Ueda, N.; Takahashi, Y.; Yamamoto, S.
    Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins (1991), Biochim. Biophys. Acta, 1083, 89-93.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.31 0.003
-
 5,8,11,14,17-eicosapentaenoic acid
-
 Homo sapiens
1.13.11.31 0.0035
-
 8,11,14-eicosatrienoic acid
-
 Homo sapiens
1.13.11.31 0.008
-
 arachidonic acid
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.31 cytosol
-
 Homo sapiens 5829
-
1.13.11.31 cytosol
-
 Sus scrofa 5829
-
1.13.11.31 cytosol
-
 Bos taurus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Bos taurus
-
-
-
1.13.11.31 Homo sapiens
-
-
-
1.13.11.31 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.31
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.31 leukocyte
-
 Homo sapiens
-
1.13.11.31 leukocyte
-
 Sus scrofa
-
1.13.11.31 leukocyte
-
 Bos taurus
-
1.13.11.31 platelet
-
 Homo sapiens
-
1.13.11.31 platelet
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.13.11.31 0.3
-
-
 Homo sapiens
1.13.11.31 0.3
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 11,14,17-eicosatrienoic acid + O2 no activity with enzyme from platelet Homo sapiens ?
-
 ?
1.13.11.31 11,14,17-eicosatrienoic acid + O2 no activity with enzyme from platelet Bos taurus ?
-
 ?
1.13.11.31 11,14,17-eicosatrienoic acid + O2 enzyme from leukocyte Sus scrofa ?
-
 ?
1.13.11.31 11,14,17-eicosatrienoic acid + O2 enzyme from leukocyte Bos taurus ?
-
 ?
1.13.11.31 11,14-eicosadienoic acid + O2 no activity with enzyme from platelet Homo sapiens ?
-
 ?
1.13.11.31 11,14-eicosadienoic acid + O2 no activity with enzyme from platelet Bos taurus ?
-
 ?
1.13.11.31 11,14-eicosadienoic acid + O2 enzyme from leukocyte Sus scrofa ?
-
 ?
1.13.11.31 11,14-eicosadienoic acid + O2 enzyme from leukocyte Bos taurus ?
-
 ?
1.13.11.31 15(S)-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid + O2
-
 Sus scrofa additional information
-
 ?
1.13.11.31 15(S)-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid + O2
-
 Bos taurus additional information
-
 ?
1.13.11.31 15(S)-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid + O2 enzyme possesses 14,15-leukotriene A4 synthase activity, 8-oxygenase activity and 14-oxygenase activity Homo sapiens additional information 14R,15S-dihydroxy-5Z,8Z,10E,12E-eicosatetraenoic acid + 14S,15S-dihydroxy-5Z,8Z,10E,12E-eicosatetraenoic acid + 8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid + 8R,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid + 8R,15S-dihydroxy-5Z,9E,11E,13E-eicosatetraenoic acid + 8S,15S-dihydroxy-5Z,9E,11E,13E-eicosatetraenoic acid ?
1.13.11.31 4,7,10,13,16,19-docosahexaenoic acid + O2
-
 Homo sapiens ?
-
 ?
1.13.11.31 4,7,10,13,16,19-docosahexaenoic acid + O2
-
 Sus scrofa ?
-
 ?
1.13.11.31 4,7,10,13,16,19-docosahexaenoic acid + O2
-
 Bos taurus ?
-
 ?
1.13.11.31 5(S)-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid + O2
-
 Sus scrofa 5,12-(5S,12S)-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + 5,12-(5S,15S)-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid
-
 ?
1.13.11.31 5(S)-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid + O2 weak activity Homo sapiens 5,12-(5S,12S)-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + 5,12-(5S,15S)-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid and 5S,15S-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid are produced in a ratio of about 8:2 ?
1.13.11.31 5(S)-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid + O2 enzyme from leukocyte, no activity with enzyme from platelet Bos taurus 5,12-(5S,12S)-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + 5,12-(5S,15S)-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid
-
 ?
1.13.11.31 5,8,11,14,17-eicosapentaenoic acid + O2
-
 Homo sapiens 12-hydroxy-5,8,10,14,17-eicosapentaenoic acid
-
 ?
1.13.11.31 5,8,11,14,17-eicosapentaenoic acid + O2
-
 Sus scrofa 12-hydroxy-5,8,10,14,17-eicosapentaenoic acid
-
 ?
1.13.11.31 5,8,11,14,17-eicosapentaenoic acid + O2
-
 Bos taurus 12-hydroxy-5,8,10,14,17-eicosapentaenoic acid
-
 ?
1.13.11.31 8,11,14-eicosatrienoic acid + O2
-
 Homo sapiens 12-hydroxyeicosatrienoic acid
-
 ?
1.13.11.31 8,11,14-eicosatrienoic acid + O2
-
 Sus scrofa 12-hydroxyeicosatrienoic acid
-
 ?
1.13.11.31 8,11,14-eicosatrienoic acid + O2
-
 Bos taurus 12-hydroxyeicosatrienoic acid
-
 ?
1.13.11.31 alpha-linolenic acid + O2 no activity with enzyme from platelet Homo sapiens ?
-
 ?
1.13.11.31 alpha-linolenic acid + O2 no activity with enzyme from platelet Bos taurus ?
-
 ?
1.13.11.31 alpha-linolenic acid + O2 activity with enzyme from leukocyte Sus scrofa ?
-
 ?
1.13.11.31 alpha-linolenic acid + O2 activity with enzyme from leukocyte Bos taurus ?
-
 ?
1.13.11.31 arachidonate + O2 i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 arachidonate + O2 i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid Sus scrofa (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 arachidonate + O2 i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid Bos taurus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 gamma-linolenic acid + O2
-
 Sus scrofa 10-hydroxy-octadeca-6Z,8E,12Z-trienoic acid
-
 ?
1.13.11.31 gamma-linolenic acid + O2 weak activity Homo sapiens 10-hydroxy-octadeca-6Z,8E,12Z-trienoic acid
-
 ?
1.13.11.31 gamma-linolenic acid + O2 enzyme from leukocyte, no activity with enzyme from platelet Bos taurus 10-hydroxy-octadeca-6Z,8E,12Z-trienoic acid
-
 ?
1.13.11.31 linoleic acid + O2 no activity with enzyme from platelet Homo sapiens 13(S)-hydroperoxy-9Z,11E-octadecadienoic acid
-
 ?
1.13.11.31 linoleic acid + O2 no activity with enzyme from platelet Bos taurus 13(S)-hydroperoxy-9Z,11E-octadecadienoic acid
-
 ?
1.13.11.31 linoleic acid + O2 enzyme from leukocyte Sus scrofa 13(S)-hydroperoxy-9Z,11E-octadecadienoic acid
-
 ?
1.13.11.31 linoleic acid + O2 enzyme from leukocyte Bos taurus 13(S)-hydroperoxy-9Z,11E-octadecadienoic acid
-
 ?