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Literature summary extracted from
- Individual variation in hepatic aldehyde oxidase activity (2001), IUBMB Life, 51, 249-253.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.3.1 | menadione | - |
Homo sapiens |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.3.1 | 0.004 | 0.015 | benzaldehyde | - |
Homo sapiens | |
| 1.2.3.1 | 0.008 | 0.014 | N-[(2-dimethylamino)ethyl] acridine-4-carboxamide | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.2.3.1 | cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.3.1 | Fe2+ | 2 Fe/S iron centres | Homo sapiens | |
| 1.2.3.1 | Mo5+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.3.1 | additional information | Homo sapiens | enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.3.1 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.2.3.1 | liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.3.1 | 5-fluoropyrimidine + H2O + O2 | - |
Homo sapiens | 5-fluorouracil + H2O2 | - |
? | |
| 1.2.3.1 | benzaldehyde + H2O + O2 | - |
Homo sapiens | benzoic acid + H2O2 | - |
? | |
| 1.2.3.1 | additional information | enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine | Homo sapiens | ? | - |
? | |
| 1.2.3.1 | N-[(2-dimethylamino)ethyl] acridine-4-carboxamide + H2O + O2 | - |
Homo sapiens | N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.2.3.1 | AO | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.2.3.1 | 25 | - |
benzaldehyde assay at | Homo sapiens |
| 1.2.3.1 | 37 | - |
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide assay | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.2.3.1 | 7.8 | - |
assay at | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.3.1 | FAD | - |
Homo sapiens | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.3.1 | 0.0003 | 0.0086 | menadione | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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