Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Meister, A.
    Glutamine synthetase from mammalian tissues (1985), Methods Enzymol., 113, 185-199.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.1.2 alpha-ketoglutarate activates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.1.2 Ala
-
Rattus norvegicus
6.3.1.2 Carbamoyl phosphate
-
Rattus norvegicus
6.3.1.2 Gly
-
Rattus norvegicus
6.3.1.2 L-methionine sulfoximine
-
Rattus norvegicus
6.3.1.2 L-methionine sulfoximine
-
Sus scrofa
6.3.1.2 Ser
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.1.2 0.18
-
NH4+ Mg2+-stimulated Ovis aries
6.3.1.2 2.3
-
ATP ATP, Mg2+-stimulated Ovis aries
6.3.1.2 2.5
-
ATP L-Glu, Mg2+-stimulated Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.1.2 Co2+ at pH 7.2, Mg2+ is more effective than Co2+ Rattus norvegicus
6.3.1.2 Mg2+
-
Sus scrofa
6.3.1.2 Mg2+ at pH 7.2, Mg2+ is more effective than Mn2+ Rattus norvegicus
6.3.1.2 Mn2+ at pH 7.2, Mg2+ is more effective than Mn2+ Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.1.2 44000
-
x * 44000, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.3.1.2 Cricetulus griseus
-
-
-
6.3.1.2 Gallus gallus
-
-
-
6.3.1.2 Homo sapiens
-
-
-
6.3.1.2 Mammalia
-
-
-
6.3.1.2 Ovis aries
-
-
-
6.3.1.2 Rattus norvegicus
-
-
-
6.3.1.2 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.1.2 brain
-
Homo sapiens
-
6.3.1.2 brain
-
Rattus norvegicus
-
6.3.1.2 brain
-
Sus scrofa
-
6.3.1.2 brain
-
Ovis aries
-
6.3.1.2 liver
-
Gallus gallus
-
6.3.1.2 liver
-
Cricetulus griseus
-
6.3.1.2 liver
-
Homo sapiens
-
6.3.1.2 liver
-
Rattus norvegicus
-
6.3.1.2 neural retina
-
Gallus gallus
-
6.3.1.2 spleen
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.1.2 8.93
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.1.2 ATP + L-Glu + NH4+
-
Gallus gallus ADP + phosphate + L-Gln
-
?
6.3.1.2 ATP + L-Glu + NH4+
-
Cricetulus griseus ADP + phosphate + L-Gln
-
?
6.3.1.2 ATP + L-Glu + NH4+
-
Mammalia ADP + phosphate + L-Gln
-
?
6.3.1.2 ATP + L-Glu + NH4+
-
Homo sapiens ADP + phosphate + L-Gln
-
?
6.3.1.2 ATP + L-Glu + NH4+
-
Sus scrofa ADP + phosphate + L-Gln
-
?
6.3.1.2 ATP + L-Glu + NH4+ enzyme can bind 8 M of ATP per mol of enzyme Ovis aries ADP + phosphate + L-Gln
-
?
6.3.1.2 ATP + L-Glu + NH4+ 1 mol of enzyme can bind 5 M ATP Rattus norvegicus ADP + phosphate + L-Gln
-
?
6.3.1.2 Gln + hydroxylamine + ADP
-
Gallus gallus gamma-Glutamylhydroxamate + NH4+ + ?
-
?
6.3.1.2 Gln + hydroxylamine + ADP
-
Cricetulus griseus gamma-Glutamylhydroxamate + NH4+ + ?
-
?
6.3.1.2 Gln + hydroxylamine + ADP
-
Homo sapiens gamma-Glutamylhydroxamate + NH4+ + ?
-
?
6.3.1.2 Gln + hydroxylamine + ADP
-
Rattus norvegicus gamma-Glutamylhydroxamate + NH4+ + ?
-
?
6.3.1.2 Gln + hydroxylamine + ADP
-
Sus scrofa gamma-Glutamylhydroxamate + NH4+ + ?
-
?
6.3.1.2 Gln + hydroxylamine + ADP
-
Ovis aries gamma-Glutamylhydroxamate + NH4+ + ?
-
?
6.3.1.2 Gln + hydroxylamine + ADP ADP or ATP required Mammalia gamma-Glutamylhydroxamate + NH4+ + ?
-
?

Subunits

EC Number Subunits Comment Organism
6.3.1.2 ? x * 44000, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.1.2 additional information
-
optimum varies from about pH 4.8 to 8.5 depending upon the nature and concentration of the divalent cation present Rattus norvegicus