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Literature summary extracted from

  • Porter, D.J.T.; Chestnut, W.G.; Merrill, B.M.; Spector, T.
    Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil (1992), J. Biol. Chem., 267, 5236-5242.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.3.1.2 dithiothreitol stabilizes against inactivation via 5-alkylyluracils Mus musculus
1.3.1.2 dithiothreitol stabilizes against inactivation via 5-alkylyluracils Homo sapiens
1.3.1.2 dithiothreitol stabilizes against inactivation via 5-alkylyluracils Rattus norvegicus
1.3.1.2 dithiothreitol stabilizes against inactivation via 5-alkylyluracils Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.2 5-Bromouracil
-
 Bos taurus
1.3.1.2 5-Bromouracil
-
 Homo sapiens
1.3.1.2 5-Bromouracil
-
 Mus musculus
1.3.1.2 5-Bromouracil
-
 Rattus norvegicus
1.3.1.2 5-bromvinyluracil
-
 Bos taurus
1.3.1.2 5-bromvinyluracil
-
 Homo sapiens
1.3.1.2 5-bromvinyluracil
-
 Mus musculus
1.3.1.2 5-bromvinyluracil
-
 Rattus norvegicus
1.3.1.2 5-cyanouracil
-
 Bos taurus
1.3.1.2 5-cyanouracil
-
 Homo sapiens
1.3.1.2 5-cyanouracil
-
 Mus musculus
1.3.1.2 5-cyanouracil
-
 Rattus norvegicus
1.3.1.2 5-Diazouracil
-
 Bos taurus
1.3.1.2 5-Diazouracil
-
 Homo sapiens
1.3.1.2 5-Diazouracil
-
 Mus musculus
1.3.1.2 5-Diazouracil
-
 Rattus norvegicus
1.3.1.2 5-Ethynyluracil inactivation rate is dependent on dithiothreitol content Bos taurus
1.3.1.2 5-Ethynyluracil inactivation rate is dependent on dithiothreitol content Homo sapiens
1.3.1.2 5-Ethynyluracil inactivation rate is dependent on dithiothreitol content Mus musculus
1.3.1.2 5-Ethynyluracil inactivation rate is dependent on dithiothreitol content Rattus norvegicus
1.3.1.2 5-propynyluracil
-
 Bos taurus
1.3.1.2 5-propynyluracil
-
 Homo sapiens
1.3.1.2 5-propynyluracil
-
 Mus musculus
1.3.1.2 5-propynyluracil
-
 Rattus norvegicus
1.3.1.2 5-trifluoromethyluracil
-
 Bos taurus
1.3.1.2 5-trifluoromethyluracil
-
 Homo sapiens
1.3.1.2 5-trifluoromethyluracil
-
 Mus musculus
1.3.1.2 5-trifluoromethyluracil
-
 Rattus norvegicus
1.3.1.2 additional information no inhibition or inactivation with 5-nitro-, 5-fluoro-,5-carbamido-, 5-formyl-, 5-acetamido-, 5-hydroxymethyl- or 5-chlorouracil Bos taurus
1.3.1.2 additional information no inhibition or inactivation with 5-nitro-, 5-fluoro-,5-carbamido-, 5-formyl-, 5-acetamido-, 5-hydroxymethyl- or 5-chlorouracil Homo sapiens
1.3.1.2 additional information no inhibition or inactivation with 5-nitro-, 5-fluoro-,5-carbamido-, 5-formyl-, 5-acetamido-, 5-hydroxymethyl- or 5-chlorouracil Mus musculus
1.3.1.2 additional information no inhibition or inactivation with 5-nitro-, 5-fluoro-,5-carbamido-, 5-formyl-, 5-acetamido-, 5-hydroxymethyl- or 5-chlorouracil Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.2 Bos taurus
-
-
-
1.3.1.2 Homo sapiens
-
-
-
1.3.1.2 Mus musculus
-
-
-
1.3.1.2 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.2 dihydrothymine + NADP+
-
 Mus musculus thymine + NADPH
-
 r
1.3.1.2 dihydrothymine + NADP+
-
 Homo sapiens thymine + NADPH
-
 r
1.3.1.2 dihydrothymine + NADP+
-
 Rattus norvegicus thymine + NADPH
-
 r
1.3.1.2 dihydrothymine + NADP+
-
 Bos taurus thymine + NADPH
-
 r
1.3.1.2 thymine + NADPH
-
 Mus musculus dihydrothymine + NADP+
-
 ?
1.3.1.2 thymine + NADPH
-
 Homo sapiens dihydrothymine + NADP+
-
 ?
1.3.1.2 thymine + NADPH
-
 Rattus norvegicus dihydrothymine + NADP+
-
 ?
1.3.1.2 thymine + NADPH
-
 Bos taurus dihydrothymine + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.2 NADPH
-
 Mus musculus
1.3.1.2 NADPH
-
 Homo sapiens
1.3.1.2 NADPH
-
 Rattus norvegicus
1.3.1.2 NADPH
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.2 additional information
-
 additional information for 5-ethynyl-, 5-diazo-, 5-cyano-, 5-bromvinyl-, 5-propynyl-, 5-bromo- and 5-trifluoromethyluracil Mus musculus
1.3.1.2 additional information
-
 additional information for 5-ethynyl-, 5-diazo-, 5-cyano-, 5-bromvinyl-, 5-propynyl-, 5-bromo- and 5-trifluoromethyluracil Homo sapiens
1.3.1.2 additional information
-
 additional information for 5-ethynyl-, 5-diazo-, 5-cyano-, 5-bromvinyl-, 5-propynyl-, 5-bromo- and 5-trifluoromethyluracil Rattus norvegicus
1.3.1.2 additional information
-
 additional information for 5-ethynyl-, 5-diazo-, 5-cyano-, 5-bromvinyl-, 5-propynyl-, 5-bromo- and 5-trifluoromethyluracil Bos taurus