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Literature summary extracted from
- Characterization of aldehyde dehydrogenase from HTC rat hepatoma cells (1985), Biochim. Biophys. Acta, 843, 180-185.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.5 | Disulfiram | 0.025 mM or 0.05 mM, 99% inhibition of activity with NADP+, 60% inhibition of activity with NAD+ | Rattus norvegicus |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.1.5 | 0.02 | - |
NAD+ | reaction with propanal | Rattus norvegicus | |
| 1.2.1.5 | 0.3 | - |
benzaldehyde | - |
Rattus norvegicus | |
| 1.2.1.5 | 0.35 | - |
NADP+ | reaction with benzaldehyde | Rattus norvegicus | |
| 1.2.1.5 | 2.9 | - |
propanal | - |
Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.5 | 110000 | - |
gel filtration | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.1.5 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.2.1.5 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.2.1.5 | HTC cell | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.5 | 17.91 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.5 | benzaldehyde + NADP+ | - |
Rattus norvegicus | benzoate + NADPH | - |
? | |
| 1.2.1.5 | propanal + NAD+ + H2O | - |
Rattus norvegicus | propionate + NADH + H+ | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.5 | 55 | - |
less than 10% of the activity with NAD+ and NADP+ remains after 2 min | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.5 | 8.5 | - |
reaction with benzaldehyde and NADP+ | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.5 | NAD+ | prefers NADP+ over NAD+ | Rattus norvegicus | |
| 1.2.1.5 | NADP+ | prefers NADP+ over NAD+ | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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