Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Downes, J.E.; Holmes, R.S.
    Purification and properties of murine corneal aldehyde dehydrogenase (1993), Biochem. Mol. Biol. Int., 30, 525-535.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.5 p-hydroxymercuribenzoate
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.5 0.03
-
 4-hydroxy-2-nonenal
-
 Mus musculus
1.2.1.5 0.06
-
 NAD+
-
 Mus musculus
1.2.1.5 0.08
-
 hexanal
-
 Mus musculus
1.2.1.5 0.11
-
 benzaldehyde
-
 Mus musculus
1.2.1.5 0.12
-
 trans-2-hexenal
-
 Mus musculus
1.2.1.5 1.4
-
 NADP+
-
 Mus musculus
1.2.1.5 15.63
-
 acetaldehyde
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.5 59000
-
 2 * 59000, SDS-PAGE Mus musculus
1.2.1.5 110000
-
 gel filtration Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.5 additional information Mus musculus dual role for the corneal enzyme in providing the eye with protection against UV-B light: by oxidizing aldehydes generated through light-induced lipid peroxidation and by direct absorption of UV-B light by the enzyme ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.5 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.5
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.5 cornea
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.5 5.51
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.5 4-hydroxy-2-nonenal + NADP+ + H2O
-
 Mus musculus 4-hydroxy-2-nonenoic acid + NADPH + H+
-
 r
1.2.1.5 acetaldehyde + NAD+ + H2O
-
 Mus musculus acetate + NADH + H+
-
 ?
1.2.1.5 benzaldehyde + NAD+ + H2O
-
 Mus musculus benzoate + NADH + H+
-
 ?
1.2.1.5 benzaldehyde + NADP+
-
 Mus musculus benzoate + NADPH
-
 ?
1.2.1.5 hexanal + NAD+ + H2O
-
 Mus musculus hexanoate + NADH + H+
-
 ?
1.2.1.5 malondialdehyde + NAD+
-
 Mus musculus ? + NADH
-
 ?
1.2.1.5 additional information enzyme prefers aldehyde products of lipid peroxidation as substrates Mus musculus ?
-
 ?
1.2.1.5 additional information dual role for the corneal enzyme in providing the eye with protection against UV-B light: by oxidizing aldehydes generated through light-induced lipid peroxidation and by direct absorption of UV-B light by the enzyme Mus musculus ?
-
 ?
1.2.1.5 trans-2-hexenal + NAD+
-
 Mus musculus trans-2-hexenoate + NADH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.5 dimer 2 * 59000, SDS-PAGE Mus musculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.2.1.5 18.8
-
 NAD+ reaction with benzyladehyde Mus musculus
1.2.1.5 20.9
-
 benzaldehyde
-
 Mus musculus
1.2.1.5 26.1
-
 4-hydroxy-2-nonenal
-
 Mus musculus
1.2.1.5 33.1
-
 NADP+ reaction with benzaldehyde Mus musculus
1.2.1.5 33.5
-
 acetaldehyde
-
 Mus musculus
1.2.1.5 34
-
 hexanal
-
 Mus musculus
1.2.1.5 35.1
-
 trans-2-hexenal
-
 Mus musculus