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Literature summary extracted from

  • Coleman, M.; Vontas, J.G.; Hemingway, J.
    Molecular characterization of the amplified aldehyde oxidase from insecticide resistant Culex quinquefasciatus (2002), Eur. J. Biochem., 269, 768-779.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.3
-
 Culex quinquefasciatus
1.2.3.1 cloning of cDNA Culex quinquefasciatus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 Atrazine
-
 Culex quinquefasciatus
1.2.1.3 diazinon
-
 Culex quinquefasciatus
1.2.1.3 menadione
-
 Culex quinquefasciatus
1.2.1.3 methadone
-
 Culex quinquefasciatus
1.2.1.3 methidathione
-
 Culex quinquefasciatus
1.2.1.3 parathion
-
 Culex quinquefasciatus
1.2.1.3 profidane
-
 Culex quinquefasciatus
1.2.1.3 S-triazine
-
 Culex quinquefasciatus
1.2.1.3 thiabendazole
-
 Culex quinquefasciatus
1.2.3.1 methadone 0.1 mM, 68% inhibition Culex quinquefasciatus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.3 Iron enzyme contains 2 iron-sulfur centres Culex quinquefasciatus
1.2.1.3 Molybdenum enzyme contains a molybdopterin binding domain Culex quinquefasciatus
1.2.3.1 additional information cDNA encodes a protein with 2 predicted iron-sulfur centres, there is a highly conserved molybdopterin cofactor binding site between residues 706-752 Culex quinquefasciatus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.3.1 150000
-
 2 * 150000, deduced from nucleotide sequence Culex quinquefasciatus
1.2.3.1 302000
-
 native PAGE Culex quinquefasciatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.3 additional information Culex quinquefasciatus the enzyme may play a role in insecticide resistance ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Culex quinquefasciatus
-
-
-
1.2.3.1 Culex quinquefasciatus Q9NCL9 house mosquito, organophosphorus insecticide-resistant strain PelRR, aldehyde oxidase may play a role in insecticide resistance
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 larva
-
 Culex quinquefasciatus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 acetaldehyde + NAD+ + H2O
-
 Culex quinquefasciatus acetate + NADH + H+
-
 ?
1.2.1.3 benzaldehyde + NAD+ + H2O
-
 Culex quinquefasciatus benzoate + NADH + H+
-
 ?
1.2.1.3 additional information the enzyme may play a role in insecticide resistance Culex quinquefasciatus ?
-
 ?
1.2.3.1 acetaldehyde + H2O + O2
-
 Culex quinquefasciatus acetate + H2O2
-
 ?
1.2.3.1 benzaldehyde + H2O + O2
-
 Culex quinquefasciatus benzoate + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.3.1 dimer 2 * 150000, deduced from nucleotide sequence Culex quinquefasciatus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Culex quinquefasciatus