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Literature summary extracted from

  • Schiavo, G.; Rossetto, O.; Catsicas, S.; Polverino de Laureto, P.; DasGupta, B.R.; Benfenati, F.; Montecucco, C.
    Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E (1993), J. Biol. Chem., 268, 23784-23787.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.69 captopril
-
 Clostridium sp.
3.4.24.69 EDTA
-
 Clostridium sp.

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.69 Zinc zinc-dependent endopeptidase Clostridium sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.69 Synaptosome-associated protein + H2O Clostridium sp. i.e. SNAP 25, protein of presynaptic membrane ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.69 Clostridium sp.
-
 F
-
3.4.24.69 Clostridium sp.
-
 serotypes BoNT/A, B, D, E
-
3.4.24.69 Clostridium sp. F
-
 F
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.69 additional information the botulinum neurotoxins are divided into two groups: the A-E type and the B-D-F-tetanus toxin type Clostridium sp. ?
-
 ?
3.4.24.69 additional information N-ethylmaleimide sensitive factor (i.e. NSF), alpha/beta-SNAP or gamma-SNAP Clostridium sp. ?
-
 ?
3.4.24.69 additional information the botulinum neurotoxins are divided into two groups: the A-E type and the B-D-F-tetanus toxin type Clostridium sp. F ?
-
 ?
3.4.24.69 additional information N-ethylmaleimide sensitive factor (i.e. NSF), alpha/beta-SNAP or gamma-SNAP Clostridium sp. F ?
-
 ?
3.4.24.69 Synaptobrevin + H2O i.e. VAMP, neuronal vesicle-associated membrane protein, MW 19000, with 2 isoforms in human, chicken, in rat brain: synaptobrevin/VAMP-1 and synaptobrevin/VAMP-2, cleaves at Gln76-Phe77, the same site as botulin neurotoxin B Clostridium sp. Hydrolyzed synaptobrevin
-
 ?
3.4.24.69 Synaptobrevin + H2O serotype BoNT/D: cleavage at Lys61-Leu62 Clostridium sp. Hydrolyzed synaptobrevin
-
 ?
3.4.24.69 Synaptobrevin + H2O carrying synaptobrevin/VAMP-2 Clostridium sp. Hydrolyzed synaptobrevin
-
 ?
3.4.24.69 Synaptobrevin + H2O both isoforms are cleaved at the same rate Clostridium sp. Hydrolyzed synaptobrevin
-
 ?
3.4.24.69 Synaptobrevin + H2O carrying Val76 instead of Gln76 is not hydrolyzed by serotype BoNT/B Clostridium sp. Hydrolyzed synaptobrevin
-
 ?
3.4.24.69 Synaptobrevin + H2O highly specific neurotoxins Clostridium sp. Hydrolyzed synaptobrevin
-
 ?
3.4.24.69 Synaptobrevin + H2O i.e. VAMP, neuronal vesicle-associated membrane protein, MW 19000, with 2 isoforms in human, chicken, in rat brain: synaptobrevin/VAMP-1 and synaptobrevin/VAMP-2, cleaves at Gln76-Phe77, the same site as botulin neurotoxin B Clostridium sp. F Hydrolyzed synaptobrevin
-
 ?
3.4.24.69 Synaptobrevin + H2O serotype BoNT/D: cleavage at Lys61-Leu62 Clostridium sp. F Hydrolyzed synaptobrevin
-
 ?
3.4.24.69 Synaptobrevin + H2O carrying synaptobrevin/VAMP-2 Clostridium sp. F Hydrolyzed synaptobrevin
-
 ?
3.4.24.69 Synaptosome-associated protein + H2O serotype BoNT/A and E Clostridium sp. Hydrolyzed synaptosome-associated protein
-
 ?
3.4.24.69 Synaptosome-associated protein + H2O i.e. SNAP 25, protein of presynaptic membrane Clostridium sp. Hydrolyzed synaptosome-associated protein
-
 ?
3.4.24.69 Synaptosome-associated protein + H2O i.e. SNAP 25, protein of presynaptic membrane Clostridium sp. ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.69 37
-
 assay at Clostridium sp.