EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.68 | Proteases | activation by rapid cleavage within an exposed loop of the single inactive MW 150000 polypeptide chain and generation of active di-chain neurotoxin | Clostridium tetani | |
3.4.24.68 | Proteases | or tissue proteases | Clostridium tetani | |
3.4.24.68 | Proteases | bacterial | Clostridium tetani | |
3.4.24.69 | Proteases | activation by rapid cleavage of MW 150000 polypeptide chain and generation of active di-chain neurotoxin | Clostridium butyricum | |
3.4.24.69 | Proteases | activation by rapid cleavage of MW 150000 polypeptide chain and generation of active di-chain neurotoxin | Clostridium botulinum | |
3.4.24.69 | Proteases | activation by rapid cleavage of MW 150000 polypeptide chain and generation of active di-chain neurotoxin | Clostridium baratii | |
3.4.24.69 | Proteases | bacterial or tissue proteases | Clostridium butyricum | |
3.4.24.69 | Proteases | bacterial or tissue proteases | Clostridium botulinum | |
3.4.24.69 | Proteases | bacterial or tissue proteases | Clostridium baratii |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.68 | captopril | - |
Clostridium tetani | |
3.4.24.69 | captopril | - |
Clostridium baratii | |
3.4.24.69 | captopril | - |
Clostridium botulinum | |
3.4.24.69 | captopril | - |
Clostridium butyricum |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.24.68 | cytosol | accumulates until bacterial lysis | Clostridium tetani | 5829 | - |
3.4.24.69 | cytosol | accumulates until bacterial lysis | Clostridium butyricum | 5829 | - |
3.4.24.69 | cytosol | accumulates until bacterial lysis | Clostridium botulinum | 5829 | - |
3.4.24.69 | cytosol | accumulates until bacterial lysis | Clostridium baratii | 5829 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.68 | Cobalt | zinc-dependent endoproteinase, can replace zinc | Clostridium tetani | |
3.4.24.68 | Nickel | zinc-dependent endoproteinase, can replace zinc | Clostridium tetani | |
3.4.24.68 | Zinc | zinc-dependent endoproteinase | Clostridium tetani | |
3.4.24.68 | Zinc | 1 atom zinc per molecule toxin, zinc-binding motif: His-Glu-X-X-His, nickel or cobalt can replace zinc | Clostridium tetani | |
3.4.24.69 | Zinc | contains zinc binding motif of metalloendopeptidases His-Glu-X-X-His | Clostridium butyricum | |
3.4.24.69 | Zinc | contains zinc binding motif of metalloendopeptidases His-Glu-X-X-His | Clostridium botulinum | |
3.4.24.69 | Zinc | contains zinc binding motif of metalloendopeptidases His-Glu-X-X-His | Clostridium baratii | |
3.4.24.69 | Zinc | atom absorption spectroscopy | Clostridium butyricum | |
3.4.24.69 | Zinc | atom absorption spectroscopy | Clostridium botulinum | |
3.4.24.69 | Zinc | atom absorption spectroscopy | Clostridium baratii | |
3.4.24.69 | Zinc | 1 atom of zinc per molecule botulinum neurotoxin, bound to light chain (i.e. L-chain) | Clostridium butyricum | |
3.4.24.69 | Zinc | 1 atom of zinc per molecule botulinum neurotoxin, bound to light chain (i.e. L-chain) | Clostridium botulinum | |
3.4.24.69 | Zinc | 1 atom of zinc per molecule botulinum neurotoxin, bound to light chain (i.e. L-chain) | Clostridium baratii |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.68 | synaptobrevin + H2O | Clostridium tetani | tetanus neurotoxin receptors are located on the motor neuron plasmalemma at neuromuscular junction, after binding the toxin is internalized inside vesicles of unknown nature and then translocated across the vesicle membrane | ? | - |
? | |
3.4.24.68 | synaptobrevin + H2O | Clostridium tetani | i.e. VAMP, neuronal vesicle-associated membrane protein, predominantly exposed to cytosol | ? | - |
? | |
3.4.24.68 | synaptobrevin + H2O | Clostridium tetani | enzyme disables neuroexocytosis apparatus, acts at spinal inhibitory interneurons, blocking release of various neurotransmitters to produce spastic paralysis, clostridial neurotoxins are described as the most toxic substances known | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | Clostridium butyricum | neurotoxin binds specifically to nerve cells, botulin neurotoxin-receptors are located on the motor neuron plasmalemma at neuromuscular junctions, neurotoxin binds via protein and lipid interaction, after binding it is internalized inside vesicles of unknown nature | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | Clostridium botulinum | neurotoxin binds specifically to nerve cells, botulin neurotoxin-receptors are located on the motor neuron plasmalemma at neuromuscular junctions, neurotoxin binds via protein and lipid interaction, after binding it is internalized inside vesicles of unknown nature | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | Clostridium baratii | neurotoxin binds specifically to nerve cells, botulin neurotoxin-receptors are located on the motor neuron plasmalemma at neuromuscular junctions, neurotoxin binds via protein and lipid interaction, after binding it is internalized inside vesicles of unknown nature | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | Clostridium butyricum | involved in limited hydrolysis of proteins of the neuroexocytosis apparatus, blocks release of neurotransmitter acetylcholine at neuromuscular junction | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | Clostridium botulinum | involved in limited hydrolysis of proteins of the neuroexocytosis apparatus, blocks release of neurotransmitter acetylcholine at neuromuscular junction | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | Clostridium baratii | involved in limited hydrolysis of proteins of the neuroexocytosis apparatus, blocks release of neurotransmitter acetylcholine at neuromuscular junction | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | Clostridium butyricum | causing flaccid paralysis, in contrast to spastic paralysis caused by EC 3.4.24.68, three functionally distinct domains: domain L blocks neuroexocytosis, domain HN governs cell penetration, domain HC responsible for neurospecific binding | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | Clostridium botulinum | causing flaccid paralysis, in contrast to spastic paralysis caused by EC 3.4.24.68, three functionally distinct domains: domain L blocks neuroexocytosis, domain HN governs cell penetration, domain HC responsible for neurospecific binding | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | Clostridium baratii | causing flaccid paralysis, in contrast to spastic paralysis caused by EC 3.4.24.68, three functionally distinct domains: domain L blocks neuroexocytosis, domain HN governs cell penetration, domain HC responsible for neurospecific binding | ? | - |
? | |
3.4.24.69 | synaptobrevin + H2O | Clostridium butyricum | i.e. VAMP | ? | - |
? | |
3.4.24.69 | synaptobrevin + H2O | Clostridium botulinum | i.e. VAMP | ? | - |
? | |
3.4.24.69 | synaptobrevin + H2O | Clostridium baratii | i.e. VAMP | ? | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | Clostridium butyricum | i.e. SNAP 25, protein of presynaptic membrane | ? | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | Clostridium botulinum | i.e. SNAP 25, protein of presynaptic membrane | ? | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | Clostridium baratii | i.e. SNAP 25, protein of presynaptic membrane | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.68 | Clostridium tetani | - |
all toxigenic strains synthesize only one type of neurotoxin | - |
3.4.24.69 | Clostridium baratii | - |
- |
- |
3.4.24.69 | Clostridium botulinum | - |
7 serologically different neurotoxin types: BoNT/A-G | - |
3.4.24.69 | Clostridium butyricum | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.4.24.68 | Hydrolysis of -Gln76-/-Phe- bond in synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP) | structure and mechanism | Clostridium tetani | |
3.4.24.69 | Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP), synaptosome-associated protein of 25 kDa (SNAP25) or syntaxin. No detected action on small molecule substrates | structure/function relationship | Clostridium butyricum | |
3.4.24.69 | Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP), synaptosome-associated protein of 25 kDa (SNAP25) or syntaxin. No detected action on small molecule substrates | structure/function relationship | Clostridium botulinum | |
3.4.24.69 | Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP), synaptosome-associated protein of 25 kDa (SNAP25) or syntaxin. No detected action on small molecule substrates | structure/function relationship | Clostridium baratii |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.4.24.68 | additional information | - |
in neurotoxin-injected Aplysia neurons 4-10 molecules of L-chains are sufficient to cause blockade of neurotransmitter release with a t1/2 of 20-40 min at 20°C | Clostridium tetani |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.68 | additional information | synaptobrevin-1 (with Val76 instead of Gln76) or short peptides containing the cleavage site of the target protein | Clostridium tetani | ? | - |
? | |
3.4.24.68 | additional information | no substrates are rat or chicken | Clostridium tetani | ? | - |
? | |
3.4.24.68 | Synaptobrevin + H2O | i.e. VAMP, neuronal vesicle-associated membrane protein, MW 19000, with 2 isoforms in human, chicken, in rat brain: synaptobrevin/VAMP-1 and synaptobrevin/VAMP-2, cleaves at Gln76-Phe77, the same site as botulin neurotoxin B | Clostridium tetani | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.68 | synaptobrevin + H2O | tetanus neurotoxin receptors are located on the motor neuron plasmalemma at neuromuscular junction, after binding the toxin is internalized inside vesicles of unknown nature and then translocated across the vesicle membrane | Clostridium tetani | ? | - |
? | |
3.4.24.68 | synaptobrevin + H2O | i.e. VAMP, neuronal vesicle-associated membrane protein, predominantly exposed to cytosol | Clostridium tetani | ? | - |
? | |
3.4.24.68 | synaptobrevin + H2O | enzyme disables neuroexocytosis apparatus, acts at spinal inhibitory interneurons, blocking release of various neurotransmitters to produce spastic paralysis, clostridial neurotoxins are described as the most toxic substances known | Clostridium tetani | ? | - |
? | |
3.4.24.69 | additional information | no hydrolysis of short peptides spanning the respective cleavage sites of the target proteins | Clostridium butyricum | ? | - |
? | |
3.4.24.69 | additional information | no hydrolysis of short peptides spanning the respective cleavage sites of the target proteins | Clostridium botulinum | ? | - |
? | |
3.4.24.69 | additional information | no hydrolysis of short peptides spanning the respective cleavage sites of the target proteins | Clostridium baratii | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | neurotoxin binds specifically to nerve cells, botulin neurotoxin-receptors are located on the motor neuron plasmalemma at neuromuscular junctions, neurotoxin binds via protein and lipid interaction, after binding it is internalized inside vesicles of unknown nature | Clostridium butyricum | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | neurotoxin binds specifically to nerve cells, botulin neurotoxin-receptors are located on the motor neuron plasmalemma at neuromuscular junctions, neurotoxin binds via protein and lipid interaction, after binding it is internalized inside vesicles of unknown nature | Clostridium botulinum | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | neurotoxin binds specifically to nerve cells, botulin neurotoxin-receptors are located on the motor neuron plasmalemma at neuromuscular junctions, neurotoxin binds via protein and lipid interaction, after binding it is internalized inside vesicles of unknown nature | Clostridium baratii | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | involved in limited hydrolysis of proteins of the neuroexocytosis apparatus, blocks release of neurotransmitter acetylcholine at neuromuscular junction | Clostridium butyricum | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | involved in limited hydrolysis of proteins of the neuroexocytosis apparatus, blocks release of neurotransmitter acetylcholine at neuromuscular junction | Clostridium botulinum | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | involved in limited hydrolysis of proteins of the neuroexocytosis apparatus, blocks release of neurotransmitter acetylcholine at neuromuscular junction | Clostridium baratii | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | causing flaccid paralysis, in contrast to spastic paralysis caused by EC 3.4.24.68, three functionally distinct domains: domain L blocks neuroexocytosis, domain HN governs cell penetration, domain HC responsible for neurospecific binding | Clostridium butyricum | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | causing flaccid paralysis, in contrast to spastic paralysis caused by EC 3.4.24.68, three functionally distinct domains: domain L blocks neuroexocytosis, domain HN governs cell penetration, domain HC responsible for neurospecific binding | Clostridium botulinum | ? | - |
? | |
3.4.24.69 | Neuroexocytosis multi-subunit complex + H2O | causing flaccid paralysis, in contrast to spastic paralysis caused by EC 3.4.24.68, three functionally distinct domains: domain L blocks neuroexocytosis, domain HN governs cell penetration, domain HC responsible for neurospecific binding | Clostridium baratii | ? | - |
? | |
3.4.24.69 | Proteins of neuroexocytosis apparatus + H2O | - |
Clostridium butyricum | ? | - |
? | |
3.4.24.69 | Proteins of neuroexocytosis apparatus + H2O | - |
Clostridium botulinum | ? | - |
? | |
3.4.24.69 | Proteins of neuroexocytosis apparatus + H2O | - |
Clostridium baratii | ? | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | i.e. VAMP, neuronal vesicle-associated membrane protein, MW 19000, with 2 isoforms in human, chicken, in rat brain: synaptobrevin/VAMP-1 and synaptobrevin/VAMP-2, cleaves at Gln76-Phe77, the same site as botulin neurotoxin B | Clostridium butyricum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | i.e. VAMP, neuronal vesicle-associated membrane protein, MW 19000, with 2 isoforms in human, chicken, in rat brain: synaptobrevin/VAMP-1 and synaptobrevin/VAMP-2, cleaves at Gln76-Phe77, the same site as botulin neurotoxin B | Clostridium botulinum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | i.e. VAMP, neuronal vesicle-associated membrane protein, MW 19000, with 2 isoforms in human, chicken, in rat brain: synaptobrevin/VAMP-1 and synaptobrevin/VAMP-2, cleaves at Gln76-Phe77, the same site as botulin neurotoxin B | Clostridium baratii | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | hydrolyzed by serotypes BoNT/B | Clostridium butyricum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | hydrolyzed by serotypes BoNT/B | Clostridium botulinum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | hydrolyzed by serotypes BoNT/B | Clostridium baratii | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | serotype BoNT/B: cleavage at Ser-Ala-+-Ala-Lys | Clostridium butyricum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | serotype BoNT/B: cleavage at Ser-Ala-+-Ala-Lys | Clostridium botulinum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | serotype BoNT/B: cleavage at Ser-Ala-+-Ala-Lys | Clostridium baratii | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | serotype BoNT/B: cleavage at Gln-Lys-+-Leu-Ser | Clostridium butyricum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | serotype BoNT/B: cleavage at Gln-Lys-+-Leu-Ser | Clostridium botulinum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | serotype BoNT/B: cleavage at Gln-Lys-+-Leu-Ser | Clostridium baratii | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | hydrolyzed by serotypes D, F or G | Clostridium butyricum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | hydrolyzed by serotypes D, F or G | Clostridium botulinum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | hydrolyzed by serotypes D, F or G | Clostridium baratii | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | in vitro, in synaptosomes and in injected Aplysia neurons | Clostridium butyricum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | in vitro, in synaptosomes and in injected Aplysia neurons | Clostridium botulinum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | in vitro, in synaptosomes and in injected Aplysia neurons | Clostridium baratii | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | carrying synaptobrevin/VAMP-2 | Clostridium butyricum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | carrying synaptobrevin/VAMP-2 | Clostridium botulinum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | carrying synaptobrevin/VAMP-2 | Clostridium baratii | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | carrying Val76 instead of Gln76 is not hydrolyzed by serotype BoNT/B | Clostridium butyricum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | carrying Val76 instead of Gln76 is not hydrolyzed by serotype BoNT/B | Clostridium botulinum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | carrying Val76 instead of Gln76 is not hydrolyzed by serotype BoNT/B | Clostridium baratii | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | highly specific neurotoxins | Clostridium butyricum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | highly specific neurotoxins | Clostridium botulinum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | highly specific neurotoxins | Clostridium baratii | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | serotype BoNT/B: cleavage at Ser-Gln-+-Phe-Glu (at the same site as the tetanus neurotoxin) | Clostridium butyricum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | serotype BoNT/B: cleavage at Ser-Gln-+-Phe-Glu (at the same site as the tetanus neurotoxin) | Clostridium botulinum | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | Synaptobrevin + H2O | serotype BoNT/B: cleavage at Ser-Gln-+-Phe-Glu (at the same site as the tetanus neurotoxin) | Clostridium baratii | Hydrolyzed synaptobrevin | - |
? | |
3.4.24.69 | synaptobrevin + H2O | i.e. VAMP | Clostridium butyricum | ? | - |
? | |
3.4.24.69 | synaptobrevin + H2O | i.e. VAMP | Clostridium botulinum | ? | - |
? | |
3.4.24.69 | synaptobrevin + H2O | i.e. VAMP | Clostridium baratii | ? | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | serotype BoNT/A and E | Clostridium butyricum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | serotype BoNT/A and E | Clostridium botulinum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | serotype BoNT/A and E | Clostridium baratii | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | i.e. SNAP 25, protein of presynaptic membrane | Clostridium butyricum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | i.e. SNAP 25, protein of presynaptic membrane | Clostridium botulinum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | i.e. SNAP 25, protein of presynaptic membrane | Clostridium baratii | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | in vitro, in isolated synaptosomes | Clostridium butyricum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | in vitro, in isolated synaptosomes | Clostridium botulinum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | in vitro, in isolated synaptosomes | Clostridium baratii | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | serotype BoNT/A: cleavage at Asn-Gln-+-Arg-Ala | Clostridium butyricum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | serotype BoNT/A: cleavage at Asn-Gln-+-Arg-Ala | Clostridium botulinum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | serotype BoNT/A: cleavage at Asn-Gln-+-Arg-Ala | Clostridium baratii | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | in vitro and in injected Aplysia neurons | Clostridium butyricum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | in vitro and in injected Aplysia neurons | Clostridium botulinum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | in vitro and in injected Aplysia neurons | Clostridium baratii | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | serotype BoNT/A: cleavage at Asp-Arg-+-Ile-Met | Clostridium butyricum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | serotype BoNT/A: cleavage at Asp-Arg-+-Ile-Met | Clostridium botulinum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | serotype BoNT/A: cleavage at Asp-Arg-+-Ile-Met | Clostridium baratii | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | MW 25000 | Clostridium butyricum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | MW 25000 | Clostridium botulinum | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | MW 25000 | Clostridium baratii | Hydrolyzed synaptosome-associated protein | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | i.e. SNAP 25, protein of presynaptic membrane | Clostridium butyricum | ? | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | i.e. SNAP 25, protein of presynaptic membrane | Clostridium botulinum | ? | - |
? | |
3.4.24.69 | Synaptosome-associated protein + H2O | i.e. SNAP 25, protein of presynaptic membrane | Clostridium baratii | ? | - |
? | |
3.4.24.69 | Syntaxin + H2O | in vitro, in synaptosomes and in injected Aplysia neurons | Clostridium butyricum | ? | - |
? | |
3.4.24.69 | Syntaxin + H2O | in vitro, in synaptosomes and in injected Aplysia neurons | Clostridium botulinum | ? | - |
? | |
3.4.24.69 | Syntaxin + H2O | in vitro, in synaptosomes and in injected Aplysia neurons | Clostridium baratii | ? | - |
? | |
3.4.24.69 | Syntaxin + H2O | serotype BoNT/C | Clostridium butyricum | ? | - |
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3.4.24.69 | Syntaxin + H2O | serotype BoNT/C | Clostridium botulinum | ? | - |
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3.4.24.69 | Syntaxin + H2O | serotype BoNT/C | Clostridium baratii | ? | - |
? |