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Literature summary extracted from

  • Phillips, R.S.; Sundararaju, B.; Koushik, S.V.
    The catalytic mechanism of kynureninase from Pseudomonas fluorescens: Evidence for transient quinonoid and ketimine intermediates from rapid-scanning stopped-flow spectrophotometry (1998), Biochemistry, 37, 8783-8789.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.7.1.3 medicine tryptophan metabolism Pseudomonas fluorescens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.7.1.3 benzaldehyde
-
 Pseudomonas fluorescens
3.7.1.3 o-aminoacetophenone
-
 Pseudomonas fluorescens
3.7.1.3 o-aminobenzaldehyde
-
 Pseudomonas fluorescens
3.7.1.3 o-nitrobenzaldehyde
-
 Pseudomonas fluorescens
3.7.1.3 S-(2-aminophenyl)-L-cysteine S,S-dioxide transition state analogue Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.7.1.3 L-alanine + pyridoxal 5'-phosphate Pseudomonas fluorescens
-
 pyruvate + pyridoxamine 5'-phosphate
-
 ?
3.7.1.3 L-kynurenine + H2O Pseudomonas fluorescens
-
 anthranilate + L-alanine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.7.1.3 Pseudomonas fluorescens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.7.1.3
-
 Pseudomonas fluorescens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.7.1.3 L-alanine + pyridoxal 5'-phosphate
-
 Pseudomonas fluorescens pyruvate + pyridoxamine 5'-phosphate
-
 ?
3.7.1.3 L-kynurenine + H2O
-
 Pseudomonas fluorescens anthranilate + L-alanine
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
3.7.1.3 pyridoxal 5'-phosphate
-
 Pseudomonas fluorescens