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Literature summary extracted from

  • Galamba, A.; Soetaert, K.; Buyssens, P.; Monnaie, D.; Jacobs, P.; Content, J.
    Molecular and biochemical characterization of Mycobacterium smegmatis alcohol dehydrogenase C (2001), FEMS Microbiol. Lett., 196, 51-56.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.2 medicine enzyme as a target for anti-tuberculosis and other drugs Mycolicibacterium smegmatis
1.1.1.2 medicine enzyme as a target for anti-tuberculosis and other drugs Mycobacterium leprae
1.1.1.2 medicine enzyme as a target for anti-tuberculosis and other drugs Mycobacterium tuberculosis
1.1.1.2 medicine enzyme as a target for anti-tuberculosis and other drugs Mycobacterium tuberculosis variant bovis
1.1.1.2 medicine enzyme as a target for anti-tuberculosis and other drugs Mycobacterium avium subsp. paratuberculosis
1.1.1.2 medicine enzyme may be an interesting target for development of new anti-mycobacterial agents Mycolicibacterium smegmatis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.2 gene encoding ADHC cloned and sequenced Mycolicibacterium smegmatis
1.1.1.2 gene encoding NADP-dependent alcohol dehydrogenase cloned and sequenced Mycobacterium tuberculosis variant bovis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.03
-
 octanal
-
 Mycolicibacterium smegmatis
1.1.1.2 0.04
-
 cinnamaldehyde
-
 Mycolicibacterium smegmatis
1.1.1.2 0.053
-
 benzaldehyde
-
 Mycolicibacterium smegmatis
1.1.1.2 0.215
-
 Butyraldehyde
-
 Mycolicibacterium smegmatis
1.1.1.2 0.5
-
 cinnamyl alcohol
-
 Mycolicibacterium smegmatis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.2 37100
-
 calculated from amino acid sequence Mycolicibacterium smegmatis
1.1.1.2 38000
-
 SDS-PAGE Mycolicibacterium smegmatis

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Bacillus subtilis
-
-
-
1.1.1.2 Equus sp.
-
-
-
1.1.1.2 Escherichia coli
-
-
-
1.1.1.2 Helicobacter pylori
-
-
-
1.1.1.2 Mycobacterium avium
-
-
-
1.1.1.2 Mycobacterium avium subsp. paratuberculosis
-
-
-
1.1.1.2 Mycobacterium leprae
-
-
-
1.1.1.2 Mycobacterium tuberculosis
-
 var. bovis BCG
-
1.1.1.2 Mycobacterium tuberculosis variant bovis
-
-
-
1.1.1.2 Mycolicibacterium smegmatis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
 Mycolicibacterium smegmatis
1.1.1.2
-
 Mycobacterium tuberculosis variant bovis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 liver
-
 Equus sp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.2 0.024
-
-
 Mycolicibacterium smegmatis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 benzaldehyde + NADPH
-
 Bacillus subtilis benzyl alcohol + NADP+
-
 r
1.1.1.2 benzaldehyde + NADPH
-
 Mycolicibacterium smegmatis benzyl alcohol + NADP+
-
 r
1.1.1.2 benzaldehyde + NADPH
-
 Mycobacterium avium benzyl alcohol + NADP+
-
 r
1.1.1.2 benzaldehyde + NADPH
-
 Mycobacterium leprae benzyl alcohol + NADP+
-
 r
1.1.1.2 benzaldehyde + NADPH
-
 Helicobacter pylori benzyl alcohol + NADP+
-
 r
1.1.1.2 benzaldehyde + NADPH
-
 Mycobacterium tuberculosis variant bovis benzyl alcohol + NADP+
-
 r
1.1.1.2 benzaldehyde + NADPH
-
 Mycobacterium avium subsp. paratuberculosis benzyl alcohol + NADP+
-
 r
1.1.1.2 cinnamyl alcohol + NADP+
-
 Mycolicibacterium smegmatis cinnamylaldehyde + NADPH
-
 r
1.1.1.2 n-butyraldehyde + NADPH
-
 Mycolicibacterium smegmatis n-butanol + NADP+
-
 r
1.1.1.2 n-octanal + NADPH + H+
-
 Mycolicibacterium smegmatis n-octanol + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.2 dimer
-
 Mycobacterium tuberculosis variant bovis

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 alcohol dehydrogenase C
-
 Mycolicibacterium smegmatis