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Literature summary extracted from

  • Petrash, J.M.; Srivastava, S.K.
    Purification and properties of human liver aldehyde reductases (1982), Biochim. Biophys. Acta, 707, 105-114.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.2 medicine
-
Rattus norvegicus
1.1.1.2 medicine
-
Sus scrofa
1.1.1.2 medicine inhibitors alrestatin and sorbinil, possible method of preventing neuropathy and cataractogenesis associated with diabetes Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 3,3'-tetramethylenglutaric acid
-
Gallus sp.
1.1.1.2 3,3'-tetramethylenglutaric acid
-
Homo sapiens
1.1.1.2 3,3'-tetramethylenglutaric acid
-
Rattus norvegicus
1.1.1.2 Alrestatin
-
Homo sapiens
1.1.1.2 Alrestatin
-
Ovis aries
1.1.1.2 Alrestatin
-
Rattus norvegicus
1.1.1.2 Chromone
-
Homo sapiens
1.1.1.2 Li2SO4 aldehyde reductase I inhibited by 86%, aldehyde reductase II is not affected Homo sapiens
1.1.1.2 p-mercuribenzoate aldehyde reductase I is more sensitive than aldehyde reductase II Homo sapiens
1.1.1.2 p-mercuribenzoate
-
Sus scrofa
1.1.1.2 sodium phenobarbital
-
Bos taurus
1.1.1.2 sodium phenobarbital aldehyde reductase II activity diminished by 84% Homo sapiens
1.1.1.2 sorbinil
-
Homo sapiens
1.1.1.2 sorbinil
-
Ovis aries
1.1.1.2 sorbinil
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.008
-
propionaldehyde aldehyde reductase I Homo sapiens
1.1.1.2 0.013
-
NADPH aldehyde reductase II Homo sapiens
1.1.1.2 0.022
-
NADPH aldehyde reductase I Homo sapiens
1.1.1.2 0.023
-
benzaldehyde aldehyde reductase I Homo sapiens
1.1.1.2 0.029
-
p-nitrobenzaldehyde aldehyde reductase I Homo sapiens
1.1.1.2 0.034
-
p-nitrobenzaldehyde AR2 Gallus sp.
1.1.1.2 0.042
-
pyridine 3-aldehyde AR2 Gallus sp.
1.1.1.2 0.062
-
4-Pyridinecarboxaldehyde AR2 Gallus sp.
1.1.1.2 0.062
-
p-Carboxybenzaldehyde AR3 Gallus sp.
1.1.1.2 0.082
-
m-nitrobenzaldehyde AR2 Gallus sp.
1.1.1.2 0.083
-
Butyraldehyde aldehyde reductase I Homo sapiens
1.1.1.2 0.11
-
Phenylglyoxal AR2 Gallus sp.
1.1.1.2 0.169
-
p-nitrobenzaldehyde aldehyde reductase II Homo sapiens
1.1.1.2 0.31
-
laurylaldehyde AR2 Gallus sp.
1.1.1.2 0.32
-
Indole-3-acetaldehyde AR2 Gallus sp.
1.1.1.2 0.32
-
p-Carboxybenzaldehyde AR2 Gallus sp.
1.1.1.2 0.606
-
3-Pyridinecarboxaldehyde aldehyde reductase II Homo sapiens
1.1.1.2 1.1
-
n-Butyraldehyde AR2 Gallus sp.
1.1.1.2 1.1
-
p-nitrobenzaldehyde AR3 Gallus sp.
1.1.1.2 1.18
-
3-Pyridinecarboxaldehyde aldehyde reductase I Homo sapiens
1.1.1.2 1.2
-
diacetyl AR2 Gallus sp.
1.1.1.2 1.3
-
Phenylglyoxal AR3 Gallus sp.
1.1.1.2 1.9
-
methylglyoxal AR2 Gallus sp.
1.1.1.2 2
-
n-Butyraldehyde AR3 Gallus sp.
1.1.1.2 2.8
-
o-nitrobenzaldehyde AR2 Gallus sp.
1.1.1.2 2.9
-
3-Pyridinecarboxaldehyde AR3 Gallus sp.
1.1.1.2 2.94
-
DL-glyceraldehyde aldehyde reductase II Homo sapiens
1.1.1.2 2.94
-
DL-glyceraldehyde aldehyde reductase II, at pH 7.0 and 37°C Homo sapiens
1.1.1.2 2.95
-
sodium D-glucuronate aldehyde reductase II Homo sapiens
1.1.1.2 2.95
-
sodium D-glucuronate aldehyde reductase II, at pH 7.0 and 37°C Homo sapiens
1.1.1.2 3
-
Indole-3-acetaldehyde AR3 Gallus sp.
1.1.1.2 3.2
-
methylglyoxal AR3 Gallus sp.
1.1.1.2 4
-
m-nitrobenzaldehyde AR3 Gallus sp.
1.1.1.2 4.6
-
o-nitrobenzaldehyde AR3 Gallus sp.
1.1.1.2 5.2
-
pyridine 4-aldehyde AR3 Gallus sp.
1.1.1.2 7.69
-
Butyraldehyde aldehyde reductase II Homo sapiens
1.1.1.2 9.09
-
benzaldehyde aldehyde reductase II Homo sapiens
1.1.1.2 9.9
-
glycolaldehyde AR2 Gallus sp.
1.1.1.2 12.5
-
DL-glyceraldehyde aldehyde reductase I Homo sapiens
1.1.1.2 12.5
-
DL-glyceraldehyde aldehyde reductase I, at pH 7.3 and 37°C Homo sapiens
1.1.1.2 14.28
-
propionaldehyde aldehyde reductase II Homo sapiens
1.1.1.2 500
-
D-xylose aldehyde reductase II Homo sapiens
1.1.1.2 543
-
D-galactose aldehyde reductase II Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.2 NaCl 100 mM, aldehyde reductase II slightly stimulated Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.2 32000
-
-
Rattus norvegicus
1.1.1.2 32000
-
-
Bos taurus
1.1.1.2 32000
-
-
Gallus sp.
1.1.1.2 32000
-
aldehyde reductase II, gel filtration Homo sapiens
1.1.1.2 32500
-
gel filtration, Sephadex G-100 Homo sapiens
1.1.1.2 33000
-
1 * 33000, aldehyde reductase II, SDS-PAGE Homo sapiens
1.1.1.2 35000
-
1 * 35000 + 1 * 42000,aldehyde reductase I, SDS-PAGE Homo sapiens
1.1.1.2 39000
-
1 * 39000, AR1 and AR3, SDS-PAGE Gallus sp.
1.1.1.2 72000
-
gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Bos taurus
-
bovine
-
1.1.1.2 Gallus sp.
-
chicken
-
1.1.1.2 Homo sapiens
-
human
-
1.1.1.2 Mus musculus
-
mouse
-
1.1.1.2 Ovis aries
-
sheep
-
1.1.1.2 Ovis aries
-
Suffolk-Hampshire
-
1.1.1.2 Rattus norvegicus
-
rat
-
1.1.1.2 Sus scrofa
-
pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
Mus musculus
1.1.1.2 aldehyde reductase I and II Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 brain
-
Mus musculus
-
1.1.1.2 brain
-
Homo sapiens
-
1.1.1.2 brain
-
Rattus norvegicus
-
1.1.1.2 brain
-
Sus scrofa
-
1.1.1.2 brain
-
Bos taurus
-
1.1.1.2 brain
-
Ovis aries
-
1.1.1.2 brain
-
Gallus sp.
-
1.1.1.2 erythrocyte
-
Homo sapiens
-
1.1.1.2 kidney
-
Mus musculus
-
1.1.1.2 kidney
-
Homo sapiens
-
1.1.1.2 kidney
-
Rattus norvegicus
-
1.1.1.2 kidney
-
Sus scrofa
-
1.1.1.2 kidney
-
Bos taurus
-
1.1.1.2 kidney
-
Ovis aries
-
1.1.1.2 liver
-
Mus musculus
-
1.1.1.2 liver
-
Homo sapiens
-
1.1.1.2 liver
-
Rattus norvegicus
-
1.1.1.2 liver
-
Sus scrofa
-
1.1.1.2 liver
-
Bos taurus
-
1.1.1.2 liver
-
Ovis aries
-
1.1.1.2 placenta
-
Mus musculus
-
1.1.1.2 placenta
-
Homo sapiens
-
1.1.1.2 placenta
-
Rattus norvegicus
-
1.1.1.2 placenta
-
Sus scrofa
-
1.1.1.2 placenta
-
Ovis aries
-
1.1.1.2 seminal vesicle
-
Mus musculus
-
1.1.1.2 seminal vesicle
-
Homo sapiens
-
1.1.1.2 seminal vesicle
-
Rattus norvegicus
-
1.1.1.2 seminal vesicle
-
Sus scrofa
-
1.1.1.2 seminal vesicle
-
Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.2 2.47
-
aldehyde reductase I Homo sapiens
1.1.1.2 29.62
-
aldehyde reductase II Homo sapiens

Storage Stability

EC Number Storage Stability Organism
1.1.1.2 0°C, freezing of the purified enzymes results in almost complete loss of activity, purified aldehyde reductase II is stable in 10 mM sodium phosphate buffer, pH 7, for 2-3 month, but appears to lose activity rapidly thereafter, purified aldehyde reductase I retains enzyme activity in the same buffer for about 3 months, after which enzyme activity declines Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
Homo sapiens 3-pyridinemethanol + NADP+
-
r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
Rattus norvegicus 3-pyridinemethanol + NADP+
-
r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
Sus scrofa 3-pyridinemethanol + NADP+
-
r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
Bos taurus 3-pyridinemethanol + NADP+
-
?
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
Ovis aries 3-pyridinemethanol + NADP+
-
r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
Gallus sp. 3-pyridinemethanol + NADP+
-
?
1.1.1.2 4-pyridinecarboxaldehyde + NADPH
-
Gallus sp. 4-pyridinemethanol + NADP+
-
?
1.1.1.2 benzaldehyde + NADPH
-
Homo sapiens benzyl alcohol + NADP+
-
?
1.1.1.2 D-galactose + NADPH
-
Homo sapiens ? + NADP+
-
?
1.1.1.2 D-glucuronolactone + NADPH
-
Rattus norvegicus ? + NADP+
-
?
1.1.1.2 D-glucuronolactone + NADPH
-
Sus scrofa ? + NADP+
-
?
1.1.1.2 D-glucuronolactone + NADPH
-
Gallus sp. ? + NADP+
-
?
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
Mus musculus glycerol + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
Rattus norvegicus glycerol + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
Sus scrofa glycerol + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
Ovis aries glycerol + NADP+
-
r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
Gallus sp. glycerol + NADP+
-
r
1.1.1.2 D-xylose + NADPH
-
Homo sapiens ? + NADP+
-
?
1.1.1.2 diacetyl + NADPH
-
Gallus sp. ? + NADP+
-
?
1.1.1.2 DL-glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
r
1.1.1.2 glycerol + NADP+
-
Rattus norvegicus DL-glyceraldehyde + NADPH + H+
-
r
1.1.1.2 glycerol + NADP+
-
Sus scrofa DL-glyceraldehyde + NADPH + H+
-
r
1.1.1.2 glycolaldehyde + NADPH
-
Gallus sp. ethane-1,2-diol + NADP+
-
?
1.1.1.2 indol-3-ylacetaldehyde + NADPH
-
Gallus sp. indol-3-ethanol + NADP+
-
?
1.1.1.2 L-glyceraldehyde + NADPH
-
Mus musculus glycerol + NADP+
-
r
1.1.1.2 L-glyceraldehyde + NADPH
-
Homo sapiens glycerol + NADP+
-
r
1.1.1.2 L-glyceraldehyde + NADPH
-
Rattus norvegicus glycerol + NADP+
-
r
1.1.1.2 L-glyceraldehyde + NADPH
-
Sus scrofa glycerol + NADP+
-
r
1.1.1.2 L-glyceraldehyde + NADPH
-
Ovis aries glycerol + NADP+
-
r
1.1.1.2 L-glyceraldehyde + NADPH
-
Gallus sp. glycerol + NADP+
-
r
1.1.1.2 lauryl aldehyde + NADPH
-
Gallus sp. lauryl alcohol + NADP+
-
?
1.1.1.2 m-nitrobenzaldehyde + NADPH
-
Gallus sp. m-nitrobenzylalcohol + NADP+
-
?
1.1.1.2 methylglyoxal + NADPH
-
Gallus sp. ? + NADP+
-
?
1.1.1.2 additional information
-
Sus scrofa ?
-
?
1.1.1.2 additional information
-
Bos taurus ?
-
?
1.1.1.2 additional information glucose, galactose, fructose, sorbitol, galactitol, xylitol and glycerol are no substrates Homo sapiens ?
-
?
1.1.1.2 n-butyraldehyde + NADPH
-
Homo sapiens n-butanol + NADP+
-
r
1.1.1.2 n-butyraldehyde + NADPH
-
Sus scrofa n-butanol + NADP+
-
r
1.1.1.2 n-butyraldehyde + NADPH
-
Gallus sp. n-butanol + NADP+
-
r
1.1.1.2 o-nitrobenzaldehyde + NADPH
-
Gallus sp. o-nitrobenzylalcohol + NADP+
-
?
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
Gallus sp. p-carboxybenzyl alcohol + NADP+
-
?
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
Homo sapiens p-nitrobenzylalcohol + NADP+
-
?
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
Gallus sp. p-nitrobenzylalcohol + NADP+
-
?
1.1.1.2 phenylglyoxal + NADPH
-
Gallus sp. ? + NADP+
-
?
1.1.1.2 propionaldehyde + NADPH
-
Homo sapiens propanol + NADP+
-
?
1.1.1.2 sodium D-glucuronate + NADPH + H+
-
Homo sapiens sodium L-gulonate + NADP+
-
r

Subunits

EC Number Subunits Comment Organism
1.1.1.2 dimer 1 * 35000 + 1 * 42000,aldehyde reductase I, SDS-PAGE Homo sapiens
1.1.1.2 monomer
-
Rattus norvegicus
1.1.1.2 monomer
-
Sus scrofa
1.1.1.2 monomer
-
Bos taurus
1.1.1.2 monomer 1 * 33000, aldehyde reductase II, SDS-PAGE Homo sapiens
1.1.1.2 monomer 1 * 39000, AR1 and AR3, SDS-PAGE Gallus sp.

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 L-hexonate dehydrogenase
-
Mus musculus
1.1.1.2 L-hexonate dehydrogenase
-
Homo sapiens
1.1.1.2 L-hexonate dehydrogenase
-
Bos taurus
1.1.1.2 L-hexonate dehydrogenase
-
Ovis aries

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.2 6
-
-
Rattus norvegicus
1.1.1.2 6
-
-
Gallus sp.
1.1.1.2 6
-
aldehyde reductase II Homo sapiens
1.1.1.2 6.7 6.8
-
Bos taurus
1.1.1.2 6.7 6.8 aldehyde reductase II Homo sapiens