Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Steckel, J.
    Kinetic properties and inhibition of Acinetobacter glutaminase-asparaginase (1983), Biochem. Pharmacol., 32, 971-977.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.38 6-diazo-5-oxo-L-norleucine competitive not reversible inhibition of both activities after extensive dialysis Acinetobacter glutaminasificans
3.5.1.38 acivicin competitive inhibition Acinetobacter glutaminasificans
3.5.1.38 aspartic acid competitive inhibition, Ki: glutaminase activity 0.16 mM, asparaginase activity 0.53 mM Acinetobacter glutaminasificans
3.5.1.38 azaserine competitive not reversible inhibition of both activities Acinetobacter glutaminasificans
3.5.1.38 glutamic acid competitive inhibition, Ki: glutaminase acitvity 5 mM, asparaginase activity 3 mM Acinetobacter glutaminasificans
3.5.1.38 L-asparagine competitive inhibition of glutaminase activity, Ki: 0.02 mM Acinetobacter glutaminasificans
3.5.1.38 L-methionine sulfoximine competitive inhibition Acinetobacter glutaminasificans
3.5.1.38 NH4Cl weak non-competitive inhibition of glutaminase activity Acinetobacter glutaminasificans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.38 0.041
-
L-glutamine
-
Acinetobacter glutaminasificans
3.5.1.38 0.055
-
L-asparagine
-
Acinetobacter glutaminasificans
3.5.1.38 0.083
-
L-glutamine for succinylated enzyme Acinetobacter glutaminasificans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.38 L-asparagine + H2O Acinetobacter glutaminasificans
-
L-aspartate + NH3
-
?
3.5.1.38 L-glutamine + H2O Acinetobacter glutaminasificans
-
L-glutamate + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.38 Acinetobacter glutaminasificans
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.38 to homogeneity Acinetobacter glutaminasificans

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.38 cell culture
-
Acinetobacter glutaminasificans
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.1.38 150
-
-
Acinetobacter glutaminasificans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.38 L-asparagine + H2O
-
Acinetobacter glutaminasificans L-aspartate + NH3
-
?
3.5.1.38 L-glutamine + H2O
-
Acinetobacter glutaminasificans L-glutamate + NH3
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.38 0.02
-
L-asparagine competitive inhibition of glutaminase activity Acinetobacter glutaminasificans