Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Thomas, H.; Schladt, L.; Doehmer, J.; Knehr, M.; Oesch, F.
    Rat and human liver cytosolic epoxide hydrolases: evidence for multiple forms at the level of protein and mRNA (1990), Environ. Health Perspect., 88, 49-55.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.3.2.10 1-Benzylimidazole activates mirosomal activity with styrene oxide as substrate Homo sapiens
3.3.2.10 benzil
-
 Rattus norvegicus
3.3.2.10 benzil activates mirosomal activity with styrene oxide as substrate Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.3.2.10
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.10 1-Benzylimidazole microsomal activity with cis-stilbene oxide as substrate Homo sapiens
3.3.2.10 1-trichloropropene oxide
-
 Homo sapiens
3.3.2.10 benzil inhibition of microsomal enzyme with cis-stilbene oxide, and of cytosolic enzyme forms cEHTSO and cEHCSO Homo sapiens
3.3.2.10 chalcone microsomal activity with cis-stilbene oxide as substrate, cytosolic enzyme form cEHCSO and cEHTSO Homo sapiens
3.3.2.10 styrene oxide
-
 Homo sapiens
3.3.2.10 styrene oxide
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.3.2.10 0.0017
-
 trans-stilbene oxide
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.10 cytosol
-
 Homo sapiens 5829
-
3.3.2.10 cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.3.2.10 49000
-
 x * 49000, SDS-PAGE Homo sapiens
3.3.2.10 49000
-
 x * 49000, SDS-PAGE Rattus norvegicus
3.3.2.10 60000
-
 2 * 60000, SDS-PAGE Rattus norvegicus
3.3.2.10 120000
-
 gel filtration Rattus norvegicus
3.3.2.10 130000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.10 Homo sapiens
-
-
-
3.3.2.10 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.3.2.10
-
 Rattus norvegicus
3.3.2.10 2 cytosolic enzyme forms: 1. cEHTSO, epoxide hydrolase with diagnostic substrate specificity for trans-stilbene oxide and 2. cEHCSO, epoxide hydrolase with diagnostic substrate specificity for cis-stilbene oxide Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.10 liver
-
 Homo sapiens
-
3.3.2.10 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.10 cis-stilbene oxide + H2O
-
 Homo sapiens ?
-
 ?
3.3.2.10 cis-stilbene oxide + H2O
-
 Rattus norvegicus ?
-
 ?
3.3.2.10 styrene oxide + H2O
-
 Homo sapiens styrene glycol
-
 ?
3.3.2.10 styrene oxide + H2O
-
 Rattus norvegicus styrene glycol
-
 ?
3.3.2.10 trans-stilbene oxide + H2O
-
 Homo sapiens ?
-
 ?
3.3.2.10 trans-stilbene oxide + H2O
-
 Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.3.2.10 ? x * 49000, SDS-PAGE Homo sapiens
3.3.2.10 ? x * 49000, SDS-PAGE Rattus norvegicus
3.3.2.10 dimer 2 * 60000, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.3.2.10 7.4
-
 cytosolic enzyme Homo sapiens
3.3.2.10 7.4
-
 cytosolic enzyme Rattus norvegicus
3.3.2.10 9
-
-
 Rattus norvegicus
3.3.2.10 9
-
 microsomal enzyme Homo sapiens