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Literature summary extracted from

  • Oizumi, J.; Hayakawa, K.
    Enkephalin hydrolysis by human serum biotinidase (1991), Biochim. Biophys. Acta, 1074, 433-438.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.12 1,10-phenanthroline
-
Homo sapiens
3.5.1.12 amastatin peptidase inhibitor Homo sapiens
3.5.1.12 bestatin peptidase inhibitor Homo sapiens
3.5.1.12 Hg2+
-
Homo sapiens
3.5.1.12 puromycin peptidase inhibitor Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.12 0.0051
-
epsilon-N-biotinyl-L-lysine
-
Homo sapiens
3.5.1.12 0.03
-
p-(N-biotinylamino)benzoic acid
-
Homo sapiens
3.5.1.12 0.099
-
Met-enkephalin amide
-
Homo sapiens
3.5.1.12 0.119
-
Leu-enkephalin amide
-
Homo sapiens
3.5.1.12 0.132
-
dynorphin A (1-7)
-
Homo sapiens
3.5.1.12 0.167
-
dynorphin A (1-6)
-
Homo sapiens
3.5.1.12 0.303
-
Met-enkephalin
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.12 cytoplasm
-
Homo sapiens 5737
-
3.5.1.12 cytoplasm
-
Sus scrofa 5737
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.1.12 76000
-
-
Homo sapiens
3.5.1.12 76000
-
glycoprotein with 59000 Da polypeptide core , SDS-PAGE Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.12 biotin amide + H2O Homo sapiens
-
?
-
?
3.5.1.12 biotin amide + H2O Sus scrofa
-
?
-
?
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O Homo sapiens
-
?
-
?
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O Sus scrofa
-
?
-
?
3.5.1.12 Leu-enkephalin + H2O Homo sapiens
-
?
-
?
3.5.1.12 Met-enkephalin + H2O Homo sapiens suitable natural substrate for biotinidase ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.12 Homo sapiens
-
human
-
3.5.1.12 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.12
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.12 blood serum, plasma, leukocytes Homo sapiens
-
3.5.1.12 blood serum, plasma, leukocytes Sus scrofa
-
3.5.1.12 brain
-
Homo sapiens
-
3.5.1.12 brain
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.12 biotin amide + H2O
-
Homo sapiens ?
-
?
3.5.1.12 biotin amide + H2O
-
Sus scrofa ?
-
?
3.5.1.12 dynorphin A (1-6) + H2O
-
Homo sapiens ?
-
?
3.5.1.12 dynorphin A (1-7) + H2O
-
Homo sapiens ?
-
?
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O
-
Homo sapiens biotin + L-lysine
-
ir
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O
-
Sus scrofa biotin + L-lysine
-
ir
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O
-
Homo sapiens ?
-
?
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O
-
Sus scrofa ?
-
?
3.5.1.12 Leu-enkephalin + H2O
-
Homo sapiens ?
-
?
3.5.1.12 Leu-enkephalin amide + H2O
-
Homo sapiens ?
-
?
3.5.1.12 Met-enkephalin + H2O
-
Homo sapiens ?
-
?
3.5.1.12 Met-enkephalin + H2O suitable natural substrate for biotinidase Homo sapiens ?
-
?
3.5.1.12 Met-enkephalin amide + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.12 biocytin hydrolyzing amidase
-
Homo sapiens