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Literature summary extracted from
- Studies of the 2:3-cyclic nucleotide phosphodiesterase of Haemophilus influenzae (1985), J. Gen. Microbiol., 131, 2041-2045.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.16 | 2'-AMP | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae |  |
| 3.1.4.16 | 3',5'-cAMP | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae | |
| 3.1.4.16 | 5'-ADP | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae | |
| 3.1.4.16 | 5'-AMP | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae | |
| 3.1.4.16 | 5'-ATP | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae | |
| 3.1.4.16 | 5'-CMP | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae | |
| 3.1.4.16 | 5'-GMP | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae | |
| 3.1.4.16 | 5'-UMP | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae | |
| 3.1.4.16 | adenosine | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae | |
| 3.1.4.16 | cytidine | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae | |
| 3.1.4.16 | guanosine | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae | |
| 3.1.4.16 | uridine | 2',3'-cyclic nucleotide phosphodiesterase activity | Haemophilus influenzae | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.4.16 | 0.022 | - |
bis(p-nitrophenyl)phosphate | - |
Haemophilus influenzae | |
| 3.1.4.16 | 0.033 | - |
p-Nitrophenyl phenylphosphonate | - |
Haemophilus influenzae | |
| 3.1.4.16 | 0.167 | - |
thymidine p-nitrophenyl phosphate | - |
Haemophilus influenzae | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.16 | 79000 | - |
gel filtration | Haemophilus influenzae |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.16 | Haemophilus influenzae | - |
- |
- |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.1.4.16 | 4°C or -12°C, stable | Haemophilus influenzae |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.16 | cyclic 2',3'-AMP + H2O | - |
Haemophilus influenzae | 3'-AMP | formation of adenosine without accumulation of 3'-AMP | ? | |
| 3.1.4.16 | di-p-nitrophenyl phosphate + H2O | - |
Haemophilus influenzae | p-nitrophenol + p-nitrophenyl phosphate | - |
? | |
| 3.1.4.16 | p-nitrophenyl phenylphosphonate + H2O | - |
Haemophilus influenzae | ? | - |
? | |
| 3.1.4.16 | thymidine p-nitrophenyl phosphate + H2O | - |
Haemophilus influenzae | thymidine + p-nitrophenyl phosphate | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.16 | 50 | - |
denaturation above | Haemophilus influenzae |
| 3.1.4.16 | 60 | - |
half-life: 12.2 min | Haemophilus influenzae |
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