Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | Sp1 protein, a member of the Sp/Krüppel-like factor transcription factors. Sp1, but not Sp3, binds to this promoter region of the HKalpha2 gene in mIMCD3 cells in vivo and transactivates the gene expression. siRNA knockdown of Sp1 inhibits endogenous HKalpha2 mRNA expression | Mus musculus |
Cloned (Comment) | Organism |
---|---|
gene HKalpha2, the -144/-135 element is important for HKalpha2 promoter activity, regulation of gene expression and interaction with Sp1 protein, expression analysis, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in + K+/out | Mus musculus | the H+/K+-ATPase alpha2 gene of renal collecting duct and distal colon plays a central role in potassium and acid-base homeostasis, regulation, overview. Sp1 plays an important and positive role in controlling basal HKalpha2 gene expression in mIMCD3 cells in vivo and in vitro | ADP + phosphate + H+/out + K+/in | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
collecting duct | - |
Mus musculus | - |
colon | distal | Mus musculus | - |
epithelial cell | - |
Mus musculus | - |
mIMCD-3 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in + K+/out | - |
Mus musculus | ADP + phosphate + H+/out + K+/in | - |
? | |
ATP + H2O + H+/in + K+/out | the H+/K+-ATPase alpha2 gene of renal collecting duct and distal colon plays a central role in potassium and acid-base homeostasis, regulation, overview. Sp1 plays an important and positive role in controlling basal HKalpha2 gene expression in mIMCD3 cells in vivo and in vitro | Mus musculus | ADP + phosphate + H+/out + K+/in | - |
? |
Synonyms | Comment | Organism |
---|---|---|
H+-K+-ATPase alpha2 | - |
Mus musculus |
HKalpha2 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |