Literature summary for 6.5.1.8 extracted from

Temmel, H.; Mueller, C.; Sauert, M.; Vesper, O.; Reiss, A.; Popow, J.; Martinez, J.; Moll, I.
The RNA ligase RtcB reverses MazF-induced ribosome heterogeneity in Escherichia coli (2017), Nucleic Acids Res., 45, 4708-4721.

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(truncated 16S rRNA)-3'-phosphate + 5'-hydroxy-RNA43 + GTP	endoribonuclease MazF, the toxin component of the toxin-antitoxin module mazEF, specifically cleaves the 16S rRNA of 70S ribosomes at an ACA site located at positions 15001502. Thereby, the ribosome loses a 3'-terminal 16S rRNA fragment of 43 nucleotides. RNA ligase RtcB catalyzes the religation of the truncated 16S rRNA present in specialized ribosomes. Thereby their ability to translate canonical mRNAs is fully restored	Escherichia coli	16S rRNA + GMP + diphosphate	-	?

Expression

Organism	Comment	Expression
Escherichia coli	RtcB mRNA is processed by endoribonuclease MazF and selectively translated during stress	up

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Release 2023.1 (January 2023)