Cloned (Comment) | Organism |
---|---|
ATP-dependent ligase LigB is produced in Escherichia coli as a His10-LigB fusion protein | Mycobacterium tuberculosis |
ATP-dependent ligase LigC is produced in Escherichia coli as a His10-LigC fusion protein | Mycobacterium tuberculosis |
ATP-dependent ligase LigD is produced in Escherichia coli as a His10-LigD fusion protein | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.34 | - |
ATP | ATP-dependent ligase LigB | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | Mycobacterium tuberculosis | ATP-dependent ligase LigB displays vigorous nick sealing activity in presence of NAD+ and ATP | AMP + diphosphate + (deoxyribonucleotide)n+m | - |
? | |
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | Mycobacterium tuberculosis | ATP-dependent ligase LigC displays weak nick joining activity and generates high levels of DNA adenylate intermediate | AMP + diphosphate + (deoxyribonucleotide)n+m | - |
? | |
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | Mycobacterium tuberculosis | ATP-dependent ligase LigD displays weak nick joining activity and generates high levels of DNA adenylate intermediate | AMP + diphosphate + (deoxyribonucleotide)n+m | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
ATP-dependent ligase LigB | - |
Mycobacterium tuberculosis | - |
ATP-dependent ligase LigC | - |
Mycobacterium tuberculosis | - |
ATP-dependent ligase LigD | - |
Purification (Comment) | Organism |
---|---|
His10-LigB fusion protein expressed in Escherichia coli | Mycobacterium tuberculosis |
His10-LigC fusion protein expressed in Escherichia coli | Mycobacterium tuberculosis |
His10-LigD fusion protein expressed in Escherichia coli | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | ATP-dependent ligase LigB displays vigorous nick sealing activity in presence of NAD+ and ATP | Mycobacterium tuberculosis | AMP + diphosphate + (deoxyribonucleotide)n+m | - |
? | |
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | ATP-dependent ligase LigC displays weak nick joining activity and generates high levels of DNA adenylate intermediate | Mycobacterium tuberculosis | AMP + diphosphate + (deoxyribonucleotide)n+m | - |
? | |
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | ATP-dependent ligase LigD displays weak nick joining activity and generates high levels of DNA adenylate intermediate | Mycobacterium tuberculosis | AMP + diphosphate + (deoxyribonucleotide)n+m | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | ATP-dependent ligase LigB | Mycobacterium tuberculosis |
monomer | ATP-dependent ligase LigC | Mycobacterium tuberculosis |
monomer | ATP-dependent ligase LigD | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
ATP-dependent ligase LigB | - |
Mycobacterium tuberculosis |
ATP-dependent ligase LigC | - |
Mycobacterium tuberculosis |
ATP-dependent ligase LigD | - |
Mycobacterium tuberculosis |
LigB | - |
Mycobacterium tuberculosis |
LigC | - |
Mycobacterium tuberculosis |
LigD | - |
Mycobacterium tuberculosis |
MtuLigB | - |
Mycobacterium tuberculosis |
MtuLigC | - |
Mycobacterium tuberculosis |
MtuLigD | - |
Mycobacterium tuberculosis |