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Literature summary for 6.5.1.1 extracted from

  • Robin, P.; Lindahl, T.
    DNA ligase IV from HeLa cell nuclei (1996), J. Biol. Chem., 271, 24257-24261.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(7R,9R)-idarubicin
-
Tequatrovirus T4
4',6-Diamidino-2-phenylindole
-
Tequatrovirus T4
doxorubicin
-
Tequatrovirus T4
Ethidium bromide
-
Homo sapiens
Ethidium bromide
-
Tequatrovirus T4

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
DNA ligase IV
-
Tequatrovirus T4
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
Tequatrovirus T4 AMP + diphosphate + (deoxyribonucleotide)n+m
-
?
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m joins single-strand breaks in a double stranded polydeoxynucleotide in an ATP-dependent reaction, can join the hybrid substrates oligo(dT)*poly(rA) and oligo(rA)*poly(dT) Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
?