Literature summary for 6.5.1.1 extracted from

Montecucco, A.; Lestingi, M.; Rossignol, J.M.; Elder, R.H.; Ciarrocchi, G.
Lack of discrimination between DNA ligase I and III by two classes of inhibitors, anthracyclines and distamycin (1993), Biochem. Pharmacol., 45, 1536-1539.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Anthracycline derivatives	inhibit human DNA ligase I and rat DNA ligase I and III in the poly[d(A-T)] joining assay	Homo sapiens
Anthracycline derivatives	inhibit human DNA ligase I and rat DNA ligase I and III in the poly[d(A-T)] joining assay	Rattus norvegicus
Distamycin	and derivatives, inhibit human DNA ligase I and rat DNA ligase I and III in the poly[d(A-T)] joining assay	Homo sapiens
Distamycin	and derivatives, inhibit human DNA ligase I and rat DNA ligase I and III in the poly[d(A-T)] joining assay	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	DNA ligase I	-
Rattus norvegicus	-	DNA ligase I and III	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m	-	Homo sapiens	AMP + diphosphate + (deoxyribonucleotide)n+m	-	?
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m	-	Rattus norvegicus	AMP + diphosphate + (deoxyribonucleotide)n+m	-	?

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Release 2023.1 (January 2023)