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Literature summary for 6.4.1.4 extracted from
- Immunocytochemical localization of beta-methylcrotonyl-CoA carboxylase in astroglial cells and neurons in culture (2000), J. Neurochem., 74, 1059-1067.
General Stability
| General Stability | Organism |
|---|---|
| very unstable, even in presence of potential stabilizing agents such as dithiothreitol, EDTA and glycerol 50% of beta-MCC activity is lost in 24 h | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
1 * 60000 + 1 * 72000, SDS-PAGE, Western Blot | Rattus norvegicus |
| 72000 | - |
1 * 60000 + 1 * 72000, SDS-PAGE, Western Blot | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-methylcrotonyl-CoA + HCO3- | Rattus norvegicus | irreversible catabolic pathway of leucine | ADP + phosphate + 3-methylglutaconyl-CoA | - |
ir |  |
| ATP + 3-methylcrotonyl-CoA + HCO3- | Rattus norvegicus Wistar | irreversible catabolic pathway of leucine | ADP + phosphate + 3-methylglutaconyl-CoA | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Wistar strain | - |
| Rattus norvegicus | - |
rat, Wistar | - |
| Rattus norvegicus Wistar | - |
Wistar strain | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
specific activity 500 mU/mg | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-methylcrotonyl-CoA + HCO3- | - |
Rattus norvegicus | ADP + phosphate + 3-methylglutaconyl-CoA | - |
ir | |
| ATP + 3-methylcrotonyl-CoA + HCO3- | irreversible catabolic pathway of leucine | Rattus norvegicus | ADP + phosphate + 3-methylglutaconyl-CoA | - |
ir | |
| ATP + 3-methylcrotonyl-CoA + HCO3- | - |
Rattus norvegicus Wistar | ADP + phosphate + 3-methylglutaconyl-CoA | - |
ir | |
| ATP + 3-methylcrotonyl-CoA + HCO3- | irreversible catabolic pathway of leucine | Rattus norvegicus Wistar | ADP + phosphate + 3-methylglutaconyl-CoA | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 60000 + 1 * 72000, SDS-PAGE, Western Blot | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta-MCC | - |
Rattus norvegicus |
| beta-methylcrotonyl-CoA carboxylase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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