Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A513_R514insP | insertion between residues 513 and 514 of the beta subunit, leads to partial degradation of the subunit, strongly reduced activity | Homo sapiens |
DELTA499 | beta subunit, leads to partial degradation of the subunit, strongly reduced activity | Homo sapiens |
DELTA514 | beta subunit, leads to partial degradation of the subunit, strongly reduced activity | Homo sapiens |
DELTA531 | beta subunit, no effect | Homo sapiens |
L519P | beta subunit, leads to complete degradation of the subunit, no activity | Homo sapiens |
N536D | beta subunit, leads to complete degradation of the subunit, no activity | Homo sapiens |
R512C | beta subunit, leads to partial degradation of the subunit, strongly reduced activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
800000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + propanoyl-CoA + HCO3- | Homo sapiens | key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids | ADP + phosphate + (S)-methylmalonyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + propanoyl-CoA + HCO3- | - |
Homo sapiens | ADP + phosphate + (S)-methylmalonyl-CoA | - |
? | |
ATP + propanoyl-CoA + HCO3- | key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids | Homo sapiens | ADP + phosphate + (S)-methylmalonyl-CoA | - |
? |
Subunits | Comment | Organism |
---|---|---|
dodecamer | 6 * alpha + 6 * beta | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
biotin | bound to enzyme | Homo sapiens |