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Literature summary for 6.4.1.3 extracted from

  • Rodriguez-Melendez, R.; Perez-Andrade, M.E.; Diaz, A.; Deolarte, A.; Camacho-Arroyo, I.; Ciceron, I.; Ibarra, I.; Velazquez, A.
    Differential effects of biotin deficiency and replenishment on rat liver pyruvate and propionyl-CoA carboxylases and on their mRNAs (1999), Mol. Genet. Metab., 66, 16-23.
    View publication on PubMed
Search for more literature for 6.4.1.3

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + propanoyl-CoA + HCO3- Rattus norvegicus key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 fed a biotin deficient and normal diet
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + propanoyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?
ATP + propanoyl-CoA + HCO3- key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids Rattus norvegicus ADP + phosphate + (S)-methylmalonyl-CoA
-
 ?

Subunits

Subunits Comment Organism
multimer alpha,beta, alpha subunit: 72000 Da Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
biotin bound to enzyme, very low activity when rats fed a biotin deficient diet for more than 2 weeks, in cell culture normal activity recovered 24 h after addition of biotin Rattus norvegicus