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Literature summary for 6.4.1.1 extracted from
- beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats (2002), J. Biol. Chem., 277, 39163-39168.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| phenylacetic acid | inhibition at 5 mM | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pyruvate + HCO3- | Rattus norvegicus | - |
ADP + phosphate + oxaloacetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Zucker fatty and Zucker lean rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreatic islet | increased activity in Zucker fatty rats | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pyruvate + HCO3- | - |
Rattus norvegicus | ADP + phosphate + oxaloacetate | - |
? | |
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Release 2023.1 (January 2023)
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